Induction of cell killing, micronuclei, and mutation to 6-thioguanine resistance after exposure to low-dose-rate gamma rays and tritiated water in cultured mammalian cells (L5178Y).
Induction of cell killing, micronuclei, and mutation to 6-thioguanine resistance after exposure to low-dose-rate gamma rays and tritiated water in cultured mammalian cells (L5178Y).
复制标题
培养的哺乳动物细胞 (L5178Y) 暴露于低剂量率伽马射线和氚化水后，诱导细胞杀伤、微核和 6-硫鸟嘌呤抗性突变。
作者：
A. Ueno;I. Furuno;H. Matsudaira
在培养的哺乳动物细胞(L5178Y)中，研究了低剂量率γ射线照射一段固定时间后的细胞杀伤、微核诱变和6-硫鸟嘌呤抗性突变。射线和氚水(HTO)在类似的剂量率下，从大约10至40拉德/小时。从剂量-反应关系分析，HTO…β的RBE值。射线相对于..伽马..对射线进行计算。其中细胞杀伤1.5次，微核2.0次，诱变1.8次。回顾了已报道的HTO的RBE值。
Cell killing and induction of micronuclei and mutation to 6-thioguanine resistance were studied in growing cultured mammalian cells (L5178Y) after exposure for a fixed period to low-dose-rate ..gamma.. rays and tritiated water (HTO) at comparable dose rates, from about 10 to 40 rad/hr. From the analysis of dose-response relationships, RBE values of HTO ..beta.. rays relative to ..gamma.. rays were calculated. These were 1.5 for cell killing, 2.0 for micronuclei, and 1.8 for mutation induction. Reported RBE values for HTO were reviewed.