The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites
The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites
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DOI：
10.1073/pnas.0807404105
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发表时间：
2008-10-21
影响因子：
11.1
通讯作者：
Preiser, Peter R.
中科院分区：
文献类型：
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作者：
Bozdech, Zbynek;Mok, Sachel;Preiser, Peter R.
间日疟原虫每年引起超过1亿例临床感染。由于缺乏合适的培养系统，我们对这种寄生虫生物学的了解远远落后于更致命的恶性疟原虫。在这里，我们提出了完整的转录谱在整个48小时的红细胞内循环的三个不同的A间日疟原虫株。该方法确定了预测编码与毒力和宿主病原体相互作用相关的蛋白质的基因子集的菌株特异性表达模式。与恶性疟原虫的比较揭示了参与关键细胞功能的基因表达的显着差异，这些功能是两种寄生虫物种之间生物学差异的基础。这些数据提供了对间日疟原虫生物学的深入了解，并构成了开发治疗方法的重要资源。
Plasmodium vivax causes over 100 million clinical infections each year. Primarily because of the lack of a suitable culture system, our understanding of the biology of this parasite lags significantly behind that of the more deadly species P. falciparum. Here, we present the complete transcriptional profile throughout the 48-h intraerythrocytic cycle of three distinct A vivax isolates. This approach identifies strain specific patterns of expression for subsets of genes predicted to encode proteins associated with virulence and host pathogen interactions. Comparison to A falciparum revealed significant differences in the expression of genes involved in crucial cellular functions that underpin the biological differences between the two parasite species. These data provide insights into the biology of P. vivax and constitute an important resource for the development of therapeutic approaches.