Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat
Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat
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DOI：
10.1016/s0143-4004(96)80010-5
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发表时间：
1996-03-01
期刊：
影响因子：
3.8
通讯作者：
Seckl, JR
中科院分区：
文献类型：
--
作者：
LangleyEvans, SC;Phillips, GJ;Seckl, JR
低出生体重与胎盘重量比强烈预示着高血压。两个独立的模型已经被描述来解释这种关联;低于最佳母体蛋白质营养导致胎儿营养不足，或糖皮质激素过量。给怀孕的大鼠喂食含有18%酪蛋白（对照）或9%酪蛋白的饮食，平衡能量。在妊娠第20天，终止妊娠，收集胎盘用于测定11 β-羟基类固醇脱氢酶（11 β HSD）活性。胎盘11 β HSD通常保护胎儿免受母体糖皮质激素的影响。活性被轻度蛋白限制特异性减弱（活性为33%），而糖皮质激素不敏感的对照酶的活性不变，糖皮质激素诱导的谷氨酰胺合成酶活性增加（27%），相对于对照动物胎盘中的活性。怀孕期间的营养操作显着增加收缩压（17毫米汞柱），在成年早期的后代。一个可能的共同途径，即母体环境因素可能会影响胎儿和胎盘的生长和程序疾病的推断。(C)小行星1996 W. B。桑德斯公司
Hypertension is strongly predicted by a low birthweight:placental weight ratio. Two independent models have been described to explain this association; less than optimal maternal protein nutrition leading to fetal undernutrition, or glucocorticoid excess. Pregnant rats were fed diets containing 18 per cent casein (control) or 9 per cent casein, balanced for energy. On day 20 of gestation the pregnancies were terminated and placentae collected for determination of 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) activity. Placental 11 beta HSD normally protects the fetus from the effects of maternal glucocorticoids. Activity was specifically attenuated by mild protein restriction (33 per cent in activity), whilst activities of glucocorticoid-insensitive control enzymes were unchanged and glucocorticoid-inducible glutamine synthetase activity was increased (27 per cent), relative to activity in placentae from control animals. The nutritional manipulation during pregnancy significantly increased systolic blood pressure (17 mmHg) in the resulting offspring in early adulthood. A possible common pathway whereby maternal environmental factors may influence fetal and placental growth and programme disease is inferred. (C) 1996 W. B. Saunders Company Ltd