Effects of L-carnitine administration on health-related quality of life during cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma
Effects of L-carnitine administration on health-related quality of life during cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma
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DOI：
10.1016/j.anl.2018.10.007
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发表时间：
2019-06-01
影响因子：
1.7
通讯作者：
Yoshizaki, Tomokazu
中科院分区：
文献类型：
--
作者：
Endo, Kazuhira;Ueno, Takayoshi;Yoshizaki, Tomokazu
目的：癌症相关性疲劳损害日常功能，对健康相关的生活质量(HRQOL)产生负面影响。我们先前的研究表明，以顺铂为基础的放化疗(CRT)会损害肉碱系统，肉碱缺乏会导致身体功能低下。本研究采用开放、随机、对照的前瞻性研究方法，观察L肉碱口服液对头颈部鳞状细胞癌患者血肉碱浓度、放射治疗后疲乏反应及生活质量的影响。方法：将头颈部鳞状细胞癌患者随机分为两组，L肉碱1000 mg每日1次口服，连续8周。结果：化疗结束2周后，对照组血浆肉碱平均浓度明显下降，而L-卡尼汀组治疗前后血肉碱水平无明显变化。因此，L-卡尼汀的应用保持了身体功能评分不变。结论：我们的研究表明，接受CRT治疗的患者经历了化疗所致的肉碱稳态的破坏，导致肉碱缺乏，影响了患者的生存质量。L-卡尼汀治疗有利于改善鼻咽癌患者的生存质量。(C)2018爱思唯尔B.V.保留所有权利。
Objectives: Cancer-related fatigue impairs daily functioning and negatively impacts health-related quality of life (HRQoL). Our previous study revealed that cisplatin-based chemoradiotherapy (CRT) impairs the carnitine system and carnitine deficiency leads to poor physical functioning. This open label, randomized, controlled prospective study investigated the effects of L-carnitine administration on plasma carnitine concentration, CRT-induced fatigue, and decline in HRQoL in patients with head and neck squamous cell carcinoma (HNSCC).Methods: Patients were divided into experimental group (received 1000 mg of oral liquid L-carnitine once daily for 8 weeks) and control group. The primary and secondary endpoints were the change in HRQoL scores and the change in carnitine levels, respectively, from baseline (pre-CRT) to after CRT.Results: The mean total plasma carnitine concentration in the control group decreased significantly, 2 weeks after the end of chemotherapy, while no significant differences were seen in the L-carnitine group. L-carnitine administration, therefore, kept the physical functioning score unchanged.Conclusion: Our study shows that patients who receive CRT experience chemotherapy-induced damage of carnitine homeostasis leading to deficiency of carnitine and impairment of HRQoL. L-carnitine administration is beneficial in improving the HRQoL in patients with HNSCC. (C) 2018 Elsevier B.V. All rights reserved.