Fecal microbiota transplantation: the state of the art.
Fecal microbiota transplantation: the state of the art.
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DOI：
10.4081/idr.2013.e13
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发表时间：
2013-10-09
影响因子：
3.2
通讯作者：
Petrosillo N
中科院分区：
文献类型：
--
作者：
Di Bella S;Drapeau C;García-Almodóvar E;Petrosillo N
艰难梭菌感染（CDI）是一个新出现的问题，在发病率，发病率和死亡率。目前可用的治疗方案并不总是有效的，特别是在复发性/难治性或复杂性CDI的情况下。肠道微生物群移植是一种自上世纪50年代以来就零星实践的技术，但其临床疗效直到最近才得到科学证据的支持。在这篇文章中，我们报告的病理生理基础和临床适应症，这种技术，鉴于其成本低，并证明有效性和安全性，很可能成为管理指南的一部分，困难的情况下，CDI在不久的将来。
Clostridium difficile infection (CDI) is an emerging problem in terms of incidence, morbidity and mortality. Currently available treatment options are not always effective, especially in cases of recurrent/refractory or complicated CDI. The gut microbiota transplantation is a technique that has been sporadically practiced since the ‘50s, but its clinical efficacy has only recently been supported by scientific evidence. In the present article, we report the pathophysiological basis and the clinical indications of this technique that, in light of its low cost, and proven efficacy and safety, is likely to become part of the management guidelines of difficult cases of CDI in the near future.