LONG-TERM GLYCEMIC CONTROL RELATES TO MORTALITY IN TYPE-II DIABETES
LONG-TERM GLYCEMIC CONTROL RELATES TO MORTALITY IN TYPE-II DIABETES
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DOI：
10.2337/diacare.18.12.1534
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发表时间：
1995-12-01
期刊：
影响因子：
16.2
通讯作者：
SVARDSUDD, K
中科院分区：
文献类型：
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作者：
ANDERSSON, DKG;SVARDSUDD, K
目的 - 研究长期血糖控制对新发现的 II 型糖尿病患者死亡率的影响。 研究设计和方法 - 对 1972 年至 1987 年间诊断的 411 名新发现的 II 型糖尿病患者进行随访，直至 1989 年 12 月 31 日。在 8 个随机选择的过程中收集了有关空腹血糖 (FBG) 值、体重指数 (BMI)、治疗类型和伴随疾病的临床数据年。长期血糖控制是通过这些年的 FBG 值的年平均值来衡量的。死亡率数据来自官方登记册。 结果 - 在平均 7.4 年的随访时间内，有 161 名糖尿病受试者死亡。在单变量分析中，诊断时的年龄较高；更高的基线或平均 FBG；糖尿病初期或病程中患有心脏病、脑血管疾病或肾脏疾病与较高的死亡率有关。糖尿病治疗类型或高血压诊断与死亡率无关。在多重逻辑回归分析中，诊断时年龄和平均空腹血糖与全因死亡率（P = 0.0002）、心血管死亡率（P = 0.0006）和缺血性心脏病死亡率（P = 0.03）独立相关。未发现血糖控制与非心血管死亡之间存在相关性。在 Cox 回归分析中，考虑到糖尿病诊断时的年龄，平均 FBG 与生存时间显着相关 (P < 0.05)。平均 FBG 大于或等于 7.8 mmol/1 的糖尿病受试者的死亡率比平均 FBG 的糖尿病受试者高 50%
OBJECTIVE - To study the influence of long-term glycemic control on mortality in a cohort of newly detected type II diabetic individuals.RESEARCH DESIGN AND METHODS - A total of 411 newly detected type II diabetic individuals diagnosed between 1972 and 1987 were followed until 31 December 1989. Clinical data concerning fasting blood glucose (FBG) values, body mass index (BMI), type of treatment, and concomitant diseases were collected during 8 randomly selected years. Long-term glycemic control was measured as annual averages of FBG values during these years. Mortality data were obtained from official registers.RESULTS - There were 161 diabetic subjects who died during a mean follow-up time of 7.4 years. In univariate analyses, higher age at diagnosis; higher baseline or average FBG; and the presence of heart disease, cerebrovascular disease, or kidney disease at the beginning or during the course of diabetes were related to higher mortality. Type of diabetes treatment or having a diagnosis of hypertension was not related to mortality. In multiple logistic regression analyses, age at diagnosis and average FBG were independently related to all-cause (P = 0.0002), cardiovascular (P = 0.0006), and ischemic heart disease mortality (P = 0.03). No correlations between glycemic control and noncardiovascular deaths were found. In a Cox's regression analysis, average FBG was significantly related to length of survival when age at diabetes diagnosis was taken into account (P < 0.05). Diabetic subjects with average FBG greater than or equal to 7.8 mmol/1 had 50% higher mortality compared with diabetic subjects with average FBG