Risk Factors for Psoriasis
Risk Factors for Psoriasis
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DOI：
10.1007/s13671-012-0034-6
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发表时间：
2013-03-01
影响因子：
1.6
通讯作者：
Naldi, Luigi
中科院分区：
文献类型：
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作者：
Naldi, Luigi
多因素遗传，包括遗传和环境因素之间的相互作用，是银屑病病因的假设模型。遗传性的测量表明，50%至90%的银屑病表型与遗传因素有关。其余的变化是由于环境因素。通过分析人群发病率或患病率的变化，可以初步确定候选风险因素。近几十年来，银屑病发病率呈上升趋势。分析流行病学研究可以更好地了解风险因素，从而可以定量估计感兴趣因素对疾病的贡献，并控制潜在的混杂因素。吸烟习惯、饮酒、饮食、肥胖、缺乏身体活动、感染、药物和压力性生活事件被认为是候选风险因素。令人信服的证据只存在于其中的几个，即吸烟和肥胖。了解潜在的可避免的风险因素可以为计划预防措施提供线索。
Multifactorial heredity, involving interaction between genetic and environmental factors, is the model hypothesized for psoriasis causation. Measures of heritability indicate that from 50 % to 90 % of the psoriatic phenotype is connected with genetic factors. The remaining variability is due to environmental factors. Candidate risk factors can be initially identified by analyzing variations in population incidence or prevalence. A trend toward increasing incidence of psoriasis in recent decades has been documented. Analytic epidemiologic studies offer a better insight into risk factors allowing to obtain quantitative estimates of the contribution of a factor of interest to the disease and to control for potential confounders. Smoking habits, alcohol consumption, diet, obesity, physical inactivity, infection, drugs, and stressful life events have been considered as candidate risk factors. Convincing proofs exist for only a few of them, namely smoking and obesity. Knowledge of potentially avoidable risk factors may offer clues to plan preventive measures.