SYNAPTIC INTEGRATION OF NMDA AND NON-NMDA RECEPTORS IN LARGE NEURONAL NETWORK MODELS SOLVED BY MEANS OF DIFFERENTIAL-EQUATIONS
SYNAPTIC INTEGRATION OF NMDA AND NON-NMDA RECEPTORS IN LARGE NEURONAL NETWORK MODELS SOLVED BY MEANS OF DIFFERENTIAL-EQUATIONS
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DOI：
10.1007/bf00197607
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发表时间：
1994-01-01
影响因子：
1.9
通讯作者：
WHEAL, HV
中科院分区：
文献类型：
--
作者：
BERNARD, C;GE, YC;WHEAL, HV
α函数通常用于描述不同的受体通道动力学（非NMDA、GABA（A）和GABA（B））。在本文中，我们表明，它们可以表示为简单的常微分方程的解决方案。这种替代方法相比，常用的直接求和的α功能电导在一个高层次的神经元电路模型。参数研究表明，微分方程方法大大加快了以前的求和方法。用于求解该微分方程的前向欧拉方法对于这种类型的模拟是准确的。NMDA受体通道动力学的建模进行了讨论。
Alpha functions are commonly used to describe different receptor channel kinetics (non-NMDA, GABA(A) and GABA(B)). In this paper we show that they may be represented as solutions to simple ordinary differential equations. This alternative method is compared with the commonly used direct summation of the alpha function conductances in a high-level neuronal circuit model. A parametric study shows that the differential equation method greatly speeds up the previous summation method. The forward Euler method used to solve this differential equation is shown to be accurate for this type of simulation. The modelling of NMDA receptor channel kinetics is also discussed.