Potential New Diagnostic Tool for Alzheimer's Disease Using a Linear Discriminant Function for Fourier Domain Optical Coherence Tomography
Potential New Diagnostic Tool for Alzheimer's Disease Using a Linear Discriminant Function for Fourier Domain Optical Coherence Tomography
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DOI：
10.1167/iovs.13-13629
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发表时间：
2014-05-01
影响因子：
4.4
通讯作者：
Pablo, Luis E.
中科院分区：
文献类型：
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作者：
Larrosa, Jose M.;Garcia-Martin, Elena;Pablo, Luis E.
目的.为提高视网膜和视网膜神经纤维层（RNFL）厚度参数在阿尔茨海默病（AD）诊断中的诊断能力，我们计算并验证了傅立叶域光学相干断层扫描（OCT）的线性判别函数（LDF）。我们招募了AD患者（n = 151）和年龄匹配的健康受试者（n = 61）。Cirrus和Spectralis OCT系统用于获得每个参与者的视网膜测量值和视乳头周围RNFL厚度。使用所有视网膜和RNFL OCT测量值计算LDF。绘制受试者工作特征（ROC）曲线，并在LDF和OCT设备提供的标准参数之间进行比较。敏感性和特异性用于评价诊断性能。在独立群体中使用验证集来测试LDF. MTS的性能。使用Spectralis OCT提供的RNFL厚度，使用在乳头周围扫描采集期间配准的768个点计算最佳功能（分组以获得24个均匀划分的位置）：18.325 + 0.056 x（315度-330度）- 0.122 x（300度-315度）- 0.041 x（285度-300度）+ 0.091 x（255度-270度）+ 0.041 x（225度-240度）+ 0.183 x（195度-210度）-0.108 x（150度-165度）-0.092 x（75度-90度）+0.051 x（30度-45度）。LDF的ROC曲线下面积最大为0.967。在95%固定特异性时，LDF产生最高的灵敏度值。使用Spectralis OCT设备获得的RNFL厚度测量值在健康和AD个体之间进行了区分。基于ROC曲线下面积，LDF是比任何单一参数更好的预测因子。
PURPOSE. We calculated and validated a linear discriminant function (LDF) for Fourier domain optical coherence tomography (OCT) to improve the diagnostic ability of retinal and retinal nerve fiber layer (RNFL) thickness parameters in the detection of Alzheimer's disease (AD).METHODS. We enrolled AD patients (n = 151) and age-matched, healthy subjects (n = 61). The Cirrus and Spectralis OCT systems were used to obtain retinal measurements and circumpapillary RNFL thickness for each participant. An LDF was calculated using all retinal and RNFL OCT measurements. Receiver operating characteristic (ROC) curves were plotted and compared among the LDF and the standard parameters provided by OCT devices. Sensitivity and specificity were used to evaluate diagnostic performance. A validating set was used in an independent population to test the performance of the LDF.RESULTS. The optimal function was calculated using the RNFL thickness provided by Spectralis OCT, using the 768 points registered during peripapillary scan acquisition (grouped to obtain 24 uniformly divided locations): 18.325 + 0.056 x (315 degrees-330 degrees) - 0.122 x (300 degrees-315 degrees) - 0.041 x (285 degrees-300 degrees) + 0.091 x (255 degrees-270 degrees) + 0.041 x (225 degrees-240 degrees) + 0.183 x (195 degrees-210 degrees) - 0.108 x (150 degrees-165 degrees) - 0.092 x (75 degrees-90 degrees) + 0.051 x (30 degrees-45 degrees). The largest area under the ROC curve was 0.967 for the LDF. At 95% fixed specificity, the LDF yielded the highest sensitivity values.CONCLUSIONS. Measurements of RNFL thickness obtained with the Spectralis OCT device differentiated between healthy and AD individuals. Based on the area under the ROC curve, the LDF was a better predictor than any single parameter.