Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats.
Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats.
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DOI：
10.1016/j.bbrc.2012.12.084
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发表时间：
2013-02-01
影响因子：
3.1
通讯作者：
Martyn, J. A. Jeevendra
中科院分区：
文献类型：
--
作者：
Yasuda, Yoshikazu;Fukushima, Yuji;Kaneki, Masao;Martyn, J. A. Jeevendra
关键词：
Hyperglycemia together with hepatic and muscle insulin resistance are common features in critically ill patients, and these changes are associated with enhanced inflammatory response, increased susceptibility to infection, muscle wasting, and worsened prognosis. Tight blood glucose control by intensive insulin treatment may reduce the morbidity and mortality in intensive care units. Although some anesthetics have been shown to cause insulin resistance, it remains unknown how and in which tissues insulin resistance is induced by anesthetics. Moreover, the effects of propofol, a clinically relevant intravenous anesthetic, also used in the intensive care unit for sedation, on insulin sensitivity have not yet been investigated. Euglycemic hyperinsulinemic clamp study was performed in rats anesthetized with propofol and conscious unrestrained rats. To evaluate glucose uptake in tissues and hepatic glucose output [3H]glucose and 2-deoxy[14C]glucose were infused during the clamp study. Anesthesia with propofol induced a marked whole-body insulin resistance compared with conscious rats, as reflected by significantly decreased glucose infusion rate to maintain euglycemia. Insulin-stimulated tissue glucose uptake was decreased in skeletal muscle and heart, and hepatic glucose output was increased in propofol anesthetized rats. Anesthesia with propofol induces systemic insulin resistance along with decreases in insulin-stimulated glucose uptake in skeletal and heart muscle and attenuation of the insulin-mediated suppression of hepatic glucose output in rats.
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影响因子：
5.8
作者：
Hansen, TK;Thiel, S;Van den Berghe, G
通讯作者：
Van den Berghe, G
影响因子：
3.6
作者：
Friedrich, O.
通讯作者：
Friedrich, O.
DOI：
10.1186/cc7100
发表时间：
2008
期刊：
Critical care (London, England)
影响因子：
--
作者：
Hermans G;De Jonghe B;Bruyninckx F;Van den Berghe G
通讯作者：
Van den Berghe G
DOI：
10.1097/bcr.0b013e31818481ce
发表时间：
2008-09
期刊：
Journal of burn care & research : official publication of the American Burn Association
影响因子：
--
作者：
Gauglitz GG;Herndon DN;Jeschke MG
通讯作者：
Jeschke MG
影响因子：
--
作者：
CLARK, PW;JENKINS, AB;KRAEGEN, EW
通讯作者：
KRAEGEN, EW