Suppression of EGF binding in rat liver by the hypolipidemic peroxisome proliferators, 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio-(N-beta-hydroxyethyl)ac etamide and di(2-ethylhexyl)phthalate.
Suppression of EGF binding in rat liver by the hypolipidemic peroxisome proliferators, 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio-(N-beta-hydroxyethyl)ac etamide and di(2-ethylhexyl)phthalate.
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降血脂过氧化物酶体增殖剂、4-氯-6-(2,3-xylidino)-2-嘧啶硫基-(N-β-羟乙基)乙酰胺和邻苯二甲酸二(2-乙基己基)酯抑制大鼠肝脏中EGF的结合。
DOI：
10.1093/carcin/9.1.167
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发表时间：
1988
期刊：
影响因子：
4.7
通讯作者：
Shinozuka,H
中科院分区：
文献类型：
--
作者：
Gupta,C;Hattori,A;Shinozuka,H
给大鼠日粮给予降血脂剂4-氯-6-（2,3-羟基苯基）-2-嘧啶基硫代（N-β-羟乙基）乙酰氨基（BR931）和邻苯二甲酸二（2-乙基己基）酯（DEHP） 3-35天，可显著降低肝细胞表面和细胞内[125I]EGF的结合，但不影响其结合亲和力。在BR931喂养3天后，这种减少很明显，并且BR931处理的大鼠肝细胞的减少幅度始终高于dehp处理的大鼠。BR931或DEHP喂养4周后，大鼠肝脏提取物和血清对基础日粮大鼠肝细胞的EGF结合无抑制作用。讨论了这些变化与它们的肝癌作用相关的可能意义。
Dietary administration of 4-chloro-6-(2,3-xylidino)-2- pyrimidinylthio(N-β-hydroxyethyl)acetamlde (BR931) and di(2-ethylhexyl)phthalate (DEHP), hypolipidemic agents, to rats for 3–35 days induced a marked reduction in the hepatocyte surface and intracellular binding of [125I]EGF without affecting its binding affinity. The reduction was apparent after 3 days' feeding of BR931 and the magnitude of the reduction was consistently higher in hepatocytes of BR931-treated rats than those of DEHP-treated rats. The liver extracts and the sera from rats fed BR931 or DEHP for 4 weeks showed no inhibitory effects on the EGF binding of hepatocytes from rats fed a basal diet. Possible significance of the changes in relation to their hepatocarcinogenic action was discussed.