Ambulatory Blood Pressure Monitoring–Derived Short‐Term Blood Pressure Variability in Primary Aldosteronism
Ambulatory Blood Pressure Monitoring–Derived Short‐Term Blood Pressure Variability in Primary Aldosteronism
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DOI：
10.1111/jch.12551
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发表时间：
2015-08
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影响因子：
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通讯作者：
A. Grillo;S. Bernardi;A. Rebellato;B. Fabris;M. Bardelli;J. Burrello;F. Rabbia;F. Veglio;F. Fallo;R. Carretta
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文献类型：
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作者：
A. Grillo;S. Bernardi;A. Rebellato;B. Fabris;M. Bardelli;J. Burrello;F. Rabbia;F. Veglio;F. Fallo;R. Carretta
本研究的目的是研究原发性醛固酮增多症（PA）患者（特发性醛固酮增多症（IHA）或醛固酮腺瘤（阿帕））的动态血压监测（ABPM）得出的短期血压（BP）变异性（BPV），并与原发性高血压（EH）患者和血压正常（NT）对照组进行比较。研究了30例PA患者（16例IHA和14例阿帕），30例EH患者和30例NT对照，这些患者在性别、年龄、体重指数和抗高血压治疗方面相匹配。PA患者和EH患者的24小时、日间和夜间BP的标准差（SD）; 24小时BP的加权SD; 24小时平均真实的变异性无差异（P=无显著性）。与NT对照组相比，PA患者（IHA或阿帕亚型）和EH患者的所有BPV指数均较高（P<0.001至P<0.05）。PA患者ABPM衍生的短期BPV增加，可能代表该疾病的额外心血管风险因素。醛固酮过量在BPV中的作用有待阐明。
The aim of this study was to investigate the short‐term blood pressure (BP) variability (BPV) derived from ambulatory blood pressure monitoring (ABPM) in patients with primary aldosteronism (PA), either idiopathic hyperaldosteronism (IHA) or aldosterone‐producing adenoma (APA), in comparison with patients with essential hypertension (EH) and normotensive (NT) controls. Thirty patients with PA (16 with IHA and 14 with APA), 30 patients with EH, and 30 NT controls, matched for sex, age, body mass index, and antihypertensive therapy, were studied. The standard deviation (SD) of 24‐hour, daytime, and nighttime BP; 24‐hour weighted SD of BP; and 24‐hour BP average real variability were not different between patients with PA and those with EH (P=not significant). All BPV indices were higher in patients with PA, either IHA or APA subtypes, and patients with EH, compared with NT controls (P<.001 to P<.05). ABPM‐derived short‐term BPV is increased in patients with PA, and it may represent an additional cardiovascular risk factor in this disease. The role of aldosterone excess in BPV has to be clarified.