Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression
Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression
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DOI：
10.3758/cabn.1.4.388
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发表时间：
2001-12-01
影响因子：
2.9
通讯作者：
Shinitzky, Meir
中科院分区：
文献类型：
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作者：
Tafet, Gustavo E.;Idoyaga-Vargas, Victor P.;Shinitzky, Meir
在最近的一项研究中（Tafet, Toister-Achituv, & Shinitzky, 2001），我们证明了皮质醇诱导5 -羟色胺转运体编码基因表达的增加，与随后5 -羟色胺摄取的升高有关。在正常受试者的外周血淋巴细胞中观察到这种与皮质醇体外孵育后产生的刺激作用。在目前的工作中，我们研究了皮质醇诱导的高皮质醇患者淋巴细胞中血清素摄取的增加，包括重度抑郁症患者（n = 8）和广泛性焦虑症患者（n = 12），并与正常健康对照组（n = 8）进行了比较。在对照组中观察到血清素摄取显著增加（+37% + 14,M + SD），而广泛性焦虑障碍组和重度抑郁症组在与皮质醇孵育后均未表现出血清素摄取的变化。可能是在慢性应激或抑郁状态下，由于血液皮质醇水平的长期升高，血清素转运体的增加能力已经达到极限。讨论了这一观察结果的生理和诊断意义。
In a recent study (Tafet, Toister-Achituv, & Shinitzky, 2001), we demonstrated that cortisol induces an increase in the expression of the gene coding for the serotonin transporter, associated with a subsequent elevation in the uptake of serotonin. This stimulatory effect, produced upon incubation with cortisol in vitro, was observed in peripheral blood lymphocytes from normal subjects. In the present work we investigated the cortisol-induced increase in serotonin uptake in lymphocytes from hypercortisolemic patients, including subjects with major depressive disorder (n = 8), and subjectswith generalized anxiety disorder (n = 12), in comparison with a control group of normal healthy subjects (n = 8). A significant increase in serotonin uptake (+37% + 14, M + SD) was observed in the control group, whereas neither the generalized anxiety disorder nor the major depression group exhibited changes in serotonin uptake upon incubation with cortisol. It is likely that under chronic stress or depression, the capacity for increase in serotonin transporter has reached its limit due to the chronically elevated blood cortisol level. The physiological and diagnostic implications of this observation are discussed.