Assessment of the evolution of cancer treatment therapies.
Assessment of the evolution of cancer treatment therapies.
复制标题
评估癌症治疗疗法的演变。
DOI：
10.3390/cancers3033279
复制
发表时间：
2011-08-12
期刊：
影响因子：
5.2
通讯作者：
González-Fernández A
中科院分区：
文献类型：
--
作者：
Arruebo M;Vilaboa N;Sáez-Gutierrez B;Lambea J;Tres A;Valladares M;González-Fernández A
纵观历史，癌症治疗的特点是起起落落，不仅是因为治疗无效和副作用，而且还因为在许多情况下希望和现实完全缓解和治愈。在治疗手段中，除了实体瘤的手术治疗外，抗肿瘤药物和放射治疗在某些情况下是治疗的选择。近年来，免疫疗法已成为一种重要的治疗选择，现在是许多病例的首选。纳米技术最近出现了，提供纳米结构作为新的治疗选择，用于控制药物输送，结合成像和治疗，应用热疗，以及提供定向靶向治疗等。这些疗法既可以单独使用，也可以与其他成分（抗体、多肽、叶酸等）联合使用。此外，基因疗法也为治疗提供了有希望的新方法。在这里，我们回顾了癌症治疗的发展，从化疗、手术、放射和免疫治疗开始，然后是最有前途的尖端治疗方法（基因治疗和纳米医学）。我们提供了一个历史的观点，涵盖了这些疗法进入临床实践和市场，以及它们所带来的承诺和挑战。
Cancer therapy has been characterized throughout history by ups and downs, not only due to the ineffectiveness of treatments and side effects, but also by hope and the reality of complete remission and cure in many cases. Within the therapeutic arsenal, alongside surgery in the case of solid tumors, are the antitumor drugs and radiation that have been the treatment of choice in some instances. In recent years, immunotherapy has become an important therapeutic alternative, and is now the first choice in many cases. Nanotechnology has recently arrived on the scene, offering nanostructures as new therapeutic alternatives for controlled drug delivery, for combining imaging and treatment, applying hyperthermia, and providing directed target therapy, among others. These therapies can be applied either alone or in combination with other components (antibodies, peptides, folic acid, etc.). In addition, gene therapy is also offering promising new methods for treatment. Here, we present a review of the evolution of cancer treatments, starting with chemotherapy, surgery, radiation and immunotherapy, and moving on to the most promising cutting-edge therapies (gene therapy and nanomedicine). We offer an historical point of view that covers the arrival of these therapies to clinical practice and the market, and the promises and challenges they present.