Amplitude- and velocity-dependency of rigidity measured at the wrist in Parkinson's disease
Amplitude- and velocity-dependency of rigidity measured at the wrist in Parkinson's disease
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DOI：
10.1016/j.clinph.2011.08.004
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发表时间：
2012-04-01
影响因子：
4.7
通讯作者：
Xia, Ruiping
中科院分区：
文献类型：
--
作者：
Powell, Douglas;Threlkeld, A. Joseph;Xia, Ruiping
目的：量化肌肉拉伸幅度和速率的增加对帕金森病强直的影响。方法：18 名帕金森病受试者参与了本研究。在治疗和未治疗的条件下，受试者的测试手以 50 度/秒和 280 度/秒的速度被动地移动 60 度和 90 度的手腕屈曲和伸展范围。记录关节角位置、阻力矩以及腕屈肌和伸肌的表面肌电图（EMG）。刚性分别通过归一化的工作分数和归一化的屈曲和伸展角脉冲来量化。通过平均肌电图和肌电图比率来量化拉伸和缩短肌肉的反射反应。进行了一系列方差分析，以确定振幅、速度和药物对选定变量的影响。结果：工作得分和角脉冲都表明，较大的位移振幅和较高的速度与显着更大的刚度、增加的肌电图比率和拉伸肌肉的平均肌电图相关。多巴胺能药物与硬度降低无关。结论：帕金森病硬度受肌肉拉伸的幅度和速率调节。意义：这些发现揭示了硬度的生物力学基础和生理特征，并可能为帕金森病的临床硬度评估提供信息。 (C) 2011 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: Quantify the effects of increased amplitude and rate of muscle stretch on parkinsonian rigidity.Methods: Eighteen subjects with Parkinson's disease participated in this study. Subjects' tested hand was passively displaced through 60 degrees and 90 degrees ranges of wrist flexion and extension at velocities of 50 degrees/s and 280 degrees/s in both treated and untreated conditions. Joint angular position, resistance torque, and surface electromyography (EMG) of the wrist flexors and extensors were recorded. Rigidity was quantified by normalized work scores and normalized angular impulses for flexion and extension, separately. Reflex responses of stretched and shortened muscles were quantified by mean EMG and EMG ratio. A series of ANOVAs was performed to determine the effect of amplitude, velocity and medication on selected variables.Results: Both work scores and angular impulses revealed that the larger displacement amplitude and the higher velocity were associated with significantly greater rigidity, increased EMG ratio and mean EMG of stretched muscles. Dopaminergic medication was not associated with a reduction in rigidity.Conclusions: Parkinsonian rigidity is modulated by the amplitude and rate of muscle stretch.Significance: These findings shed light on the biomechanical underpinnings and physiological characteristics of rigidity and may inform clinical rigidity assessment in Parkinson's disease. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.