Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke
Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke
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DOI：
10.1016/j.mri.2006.02.002
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发表时间：
2006-07-01
影响因子：
2.5
通讯作者：
Haga, Kristin
中科院分区：
文献类型：
--
作者：
Marshall, Ian;Karaszewski, Bartosz;Haga, Kristin
磁共振质子光谱成像（SI）技术被开发用于测量人类受试者的局部脑温度。该技术在均匀体模和四名健康志愿者中进行了验证。模拟和计算确定了理论测量精度为约+/-0.3摄氏度的个别1毫升体素。在健康志愿者中，重复测量个体体素的所有S.D.= 1.2摄氏度在临床研究中。40例急性缺血性卒中患者在26 h内（平均）进行了成像。10小时）。温度最高的地区出现异常（即。在弥散加权成像（DWI）上与正常表现的大脑进行比较。DWI“病变”区域和“正常大脑”之间的平均温差为0.17摄氏度[P < 10（-3），范围，2.45摄氏度（热）-2.17摄氏度（冷）]。SI的无创温度测量具有足够的精度，可用于中风和其他脑部疾病的病理生理学研究以及监测治疗。(C)2006年爱思唯尔公司All rights reserved.
A magnetic resonance proton spectroscopic imaging (SI) technique was developed to measure regional brain temperatures in human subjects. The technique was validated in a homogeneous phantom and in four healthy volunteers. Simulations and calculations determined the theoretical measurement precision as approximately +/-0.3 degrees C for individual 1-ml voxels. In healthy volunteers, repeated measurements oil individual voxels had all S.D.= 1.2 degrees C. In a clinical study. 40 patients with acute ischemic stroke were imaged within 26 h (mean. 10 h) of onset. Temperatures were highest in the region that appeared abnormal (i.e.. ischemic) on diffusion-weighted imaging (DWI) compared with a normal-appearing brain. The mean temperature difference between the DWI "lesion" area and the "normal brain" was 0.17 degrees C [P < 10(-3), range, 2.45 degrees C (hotter)-2.17 degrees C (cooler)]. Noninvasive temperature measurement by SI has sufficient precision to be used in Studies of pathophysiology in stroke and in other brain disorders and to monitor therapies. (C) 2006 Elsevier Inc. All rights reserved.