Antitumor effect of locally produced CD95 ligand
Antitumor effect of locally produced CD95 ligand
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DOI：
10.1038/nm0297-165
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发表时间：
1997-02-01
期刊：
影响因子：
82.9
通讯作者：
Yagita, H
中科院分区：
文献类型：
--
作者：
Seino, KI;Kayagaki, N;Yagita, H
细胞表面抗原CD95的激活可诱导携带CD95的肿瘤细胞的凋亡。在本研究中，我们研究了本地生产的CD95配体(CD95L)对CD95阴性肿瘤细胞的体内抗肿瘤作用。CD95L基因导入小鼠肿瘤细胞不影响体外生长，但在体内引起排斥反应。中性粒细胞是这种排斥反应的主要原因。还诱导了CD8(+)T细胞介导的保护性免疫，以抵御亲代肿瘤细胞的后续攻击。这些结果为CD95L在肿瘤清除中的潜在应用提供了证据，也揭示了CD95L的促炎作用。
Activation of the cell-surface antigen CD95 induces apoptosis of CD95-bearing tumor cells. In this study, we investigated the antitumor effect of locally produced CD95 ligand (CD95L) on CD95-negative tumor cells in vivo. Introduction of CD95L cDNA into murine tumor cells did not affect growth in vitro but caused rejection in vivo. Neutrophils were primarily responsible for this rejection. A CD8(+) T cell-mediated protective immunity against subsequent challenge with parental tumor cells was also elicited. These results provide evidence for the potential utility of CD95L in tumor eradication and also reveal a proinflammatory function of CD95L.