Time-varying synchronous cell ensembles during consummatory periods correlate with variable numbers of place cell spikes
Time-varying synchronous cell ensembles during consummatory periods correlate with variable numbers of place cell spikes
复制标题
完成期间随时间变化的同步细胞系综与可变数量的位置细胞尖峰相关
DOI：
10.1002/hipo.22846
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发表时间：
2018
期刊：
影响因子：
3.5
通讯作者：
Yuji Ikegaya
中科院分区：
文献类型：
--
作者：
Saichiro Yagi;Hideyoshi Igata;Yu Shikano;Yuki Aoki;Takuya Sasaki;Yuji Ikegaya
即使动物以几乎相同的行为访问相同的位置区域，海马位置细胞的尖峰率也不是恒定的，并且会发生变化。作为位置细胞尖峰变异的潜在神经生理学来源之一，我们关注神经元群的时间波动活动状态。记录执行线性轨迹任务的大鼠海马神经元的尖峰模式。在单个完成周期内，相似的神经元组在同步放电事件中更频繁地被招募，而神经元群体的不同同步放电模式往往在不同的完成周期中被识别。线性回归分析表明，完成期间神经元群的时变激活模式与跑步期间位置细胞在其位置场内的尖峰率相关。这些发现表明，位置细胞场内尖峰不仅由代表外部环境的静态输入触发，而且在很大程度上取决于神经元群体随时间变化的内部状态。
Spike rates of a hippocampal place cell are not constant and vary even when an animal visits an identical place field with nearly identical behavior. As one potential neurophysiological source underlying place cell spiking variability, we focused on the temporally fluctuating activity states of neuronal ensembles. Spike patterns of hippocampal neurons were recorded from rats performing a linear track task. Within a single consummatory period, similar sets of neurons were more frequently recruited in synchronous firing events, whereas different synchronized firing patterns of neuronal populations tended to be identified in different consummatory periods. A linear regression analysis indicated that the time‐varying activation patterns of neuronal populations during consummatory periods are correlated with the spike rates of a place cell within its place field during running. These findings suggest that place cell in‐field spiking is not only triggered by static inputs that represent external environments but also strongly depends on the time‐varying internal states of neuronal populations.