Probiotics in obese pregnancy do not reduce maternal fasting glucose: a double-blind, placebo-controlled, randomized trial (Probiotics in Pregnancy Study)
Probiotics in obese pregnancy do not reduce maternal fasting glucose: a double-blind, placebo-controlled, randomized trial (Probiotics in Pregnancy Study)
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DOI：
10.3945/ajcn.113.079723
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发表时间：
2014-06-01
影响因子：
7.1
通讯作者：
McAuliffe, Fionnuala M.
中科院分区：
文献类型：
--
作者：
Lindsay, Karen L.;Kennelly, Maria;McAuliffe, Fionnuala M.
背景：最近的研究报道了益生菌对健康孕妇的有益作用。肥胖会显著增加妊娠期糖耐量受损的风险，但益生菌在这一特定产科人群中的血糖效应需要额外的调查。目的：益生菌在妊娠期研究的目的是调查益生菌胶囊对肥胖孕妇母体空腹血糖的影响。设计：在这项安慰剂对照、双盲、随机试验中，175名妊娠早期体重指数从爱尔兰都柏林的国家妇产医院的产前门诊招募体重指数为30.0 - 39.9的孕妇。排除标准为BMI 39.9，孕前或妊娠期糖尿病，年龄
Background: Recent studies have reported beneficial effects of probiotics on maternal glycemia in healthy pregnant women. Obesity significantly increases risk of impaired glucose tolerance in pregnancy, but glycemic effects of probiotics in this specific obstetric group require additional investigation.Objective: The aim of the Probiotics in Pregnancy Study was to investigate the effect of a probiotic capsule on maternal fasting glucose in obese pregnant women.Design: In this placebo-controlled, double-blind, randomized trial, 175 pregnant women with an early pregnancy body mass index (BMI; in kg/m(2)) from 30.0 to 39.9 were recruited from antenatal clinics at the National Maternity Hospital, Dublin, Ireland. Exclusion criteria were BMI 39.9, prepregnancy or gestational diabetes, age