Epithelial-mesenchymal transition and cell cooperativity in metastasis.
Epithelial-mesenchymal transition and cell cooperativity in metastasis.
复制标题
DOI：
10.1158/0008-5472.can-09-1618
复制
发表时间：
2009-09-15
期刊：
影响因子：
11.2
通讯作者：
Hu GF
中科院分区：
文献类型：
--
作者：
Tsuji T;Ibaragi S;Hu GF
上皮-间质转化（EMT）在肿瘤转移中的作用仍存在争议。EMT被认为是肿瘤侵袭和转移的绝对条件。EMT在肿瘤侵袭和转移中的作用有三种不同的模型，包括不完全EMT、间充质-上皮转化（MET）和集体迁移。然而，对于EMT是否真的发生在癌症进展过程中，以及如果发生，它是否在转移中起着不可或缺的作用，仍然存在怀疑。我们最近的研究结果表明，EMT细胞负责降解周围的基质，使EMT和非EMT细胞的入侵和内渗。只有进入血流的非EMT细胞才能在次级部位重建集落。在这里，我们讨论了EMT在癌症转移中的作用的另一种模型，其中EMT和非EMT细胞合作完成自发转移的整个过程。
The role of epithelial-mesenchymal transition (EMT) in metastasis remains to be controversial. EMT has been postulated as an absolute requirement for tumor invasion and metastasis. Three different models including incomplete EMT, mesenchymal-epithelial transition (MET), and collective migration have been proposed for the role of EMT in cancer invasion and metastasis. However, skepticism remains as to whether EMT truly occurs during caner progression, and if it does, whether it plays an indispensible role in metastasis. Our recent findings suggest that EMT cells are responsible for degrading the surrounding matrix to enable invasion and intravasation of both EMT and non-EMT cells. Only non-EMT cell that have entered the blood stream are able to reestablish colonies in the secondary sites. Here we discuss an alternative model for the role of EMT in cancer metastasis in which EMT and non-EMT cells cooperate to complete the entire process of spontaneous metastasis.