Short-term continuous subcutaneous insulin infusion decreases the plasma vaspin levels in patients with type 2 diabetes mellitus concomitant with improvement in insulin sensitivity
Short-term continuous subcutaneous insulin infusion decreases the plasma vaspin levels in patients with type 2 diabetes mellitus concomitant with improvement in insulin sensitivity
复制标题
短期持续皮下胰岛素输注可降低 2 型糖尿病患者血浆 vaspin 水平，同时改善胰岛素敏感性
DOI：
10.1530/eje-10-1023
复制
发表时间：
2011-06-01
影响因子：
5.8
通讯作者：
Yang, Gangyi
中科院分区：
文献类型：
--
作者：
Li, Ke;Li, Ling;Yang, Gangyi
目的：目的：探讨短期持续皮下胰岛素输注（CSII）对新诊断2型糖尿病（T2 DM）患者血浆vaspin水平的影响。T2 DM组给予CSII治疗2周。在T2 DM组的16例受试者中进行了正常血糖-高胰岛素钳夹试验。用商业ELISA试剂盒测量血浆vaspin浓度。结果：T2 DM组空腹血浆vaspin水平高于IGT组和NGT组（1.83 ± 0.55vs0.51 ± 0.21vs0.53 ± 0.24 μ g/l，P < 0.05），而IGT组和NGT组之间无差异。在T2 DM患者中，CSII治疗2周后空腹血浆vaspin浓度显著降低（1.83 +/- 0.55 vs 1.19 +/- 0.57 μ g/l，P < 0.05），同时胰岛素敏感性和血糖控制显著改善。血浆vaspin水平的变化与胰岛素抵抗（IR）的改善呈正相关，胰岛素抵抗（IR）的稳态模型评估的变化。结论：血浆vaspin水平与IR相关，并在短期CSII治疗后显著降低。
Objective: To investigate the effects of short-term continuous subcutaneous insulin infusion (CSII) on plasma vaspin levels in patients with newly diagnosed type 2 diabetes mellitus (T2DM).Method: Thirty patients with severe newly diagnosed T2DM, 37 subjects with impaired glucose tolerance (IGT) and 38 gender-, age-and body mass index (BMI)-matched normal GT (NGT) controls participated in the study. The T2DM group was treated with CSII for 2 weeks. Euglycemic-hyperinsulinemic clamps were performed in 16 subjects of the T2DM group. Plasma vaspin concentrations were measured with a commercial ELISA kit. The relationship between plasma vaspin levels and metabolic parameters was also analyzed.Results: Fasting plasma vaspin levels were higher in the T2DM group than in IGT and NGT groups (1.83 +/- 0.55 vs 0.51 +/- 0.21 vs 0.53 +/- 0.24 mu g/l, P < 0.05), but there was no difference between IGT and NGT groups. In T2DM patients, fasting plasma vaspin concentrations were significantly decreased after CSII treatment for 2 weeks (1.83 +/- 0.55 vs 1.19 +/- 0.57 mu g/l, P < 0.05), accompanied by significant amelioration of insulin sensitivity and glucose control. The changes in plasma vaspin levels were positively associated with the amelioration of insulin resistance (IR) shown by the changes in homeostasis model assessment of IR.Conclusion: Plasma vaspin level is associated with IR and is significantly reduced following short-term CSII treatment.