Clinical factors affecting serum potassium concentration in cardio-renal decompensation syndrome
Clinical factors affecting serum potassium concentration in cardio-renal decompensation syndrome
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DOI：
10.1016/j.ijcard.2008.08.011
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发表时间：
2010-01-21
影响因子：
3.5
通讯作者：
Ogawa, Hisao
中科院分区：
文献类型：
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作者：
Ueno, Hirofumi;Yoshimura, Michihiro;Ogawa, Hisao
背景：肾素-血管紧张素-醛固酮系统（RAAS）抑制剂目前是治疗心力衰竭不可缺少的药物。众所周知，肾功能衰竭时容易出现高钾血症；然而，目前尚不清楚血清钾浓度如何随着心力衰竭的进展而变化。目前，心肾代偿失调综合征认为，心力衰竭和肾衰竭都会导致血清钾浓度发生类似的改变；然而，目前还没有这方面的明确报道。为了更安全有效地使用RAAS抑制剂治疗心力衰竭，有必要了解临床中影响血清钾浓度的因素。方法和结果：我们对在我机构住院的连续1035例心血管疾病患者进行了影响血清钾浓度的临床因素的研究。多元回归分析显示，与血清钾浓度升高相关的独立因素是通过估计肾小球滤过率（eGFR）评估的肾功能不全（P
Background: Renin-angiotensin-aldosterone system (RAAS) inhibitors are currently indispensable for the treatment of heart failure. It is well known that hyperkalemia is likely to occur in renal failure; however, it has not yet been clarified how the serum potassium concentration changes as heart failure progresses. Currently, the cardio-renal decompensation syndrome holds that the serum potassium concentration is altered similarly by both heart failure and renal failure; however, there are no definitive reports on this. In order to use RAAS inhibitors more safely and effectively in heart failure, it is necessary to understand the factors affecting serum potassium concentration in the clinical setting.Methods and results: We examined the clinical factors affecting serum potassium concentration in 1035 consecutive patients with cardiovascular disease who were hospitalized in our institution. Multiple regression analysis showed that the independent factors associated with an elevated serum potassium concentration were renal insufficiency evaluated by estimated glomerular filtration rate (eGFR) (P