Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017
Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017
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DOI：
10.1093/jnci/djaa128
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发表时间：
2021-06-01
影响因子：
10.3
通讯作者：
Sonawane, Kalyani
中科院分区：
文献类型：
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作者：
Deshmukh, Ashish A.;Suk, Ryan;Sonawane, Kalyani
近年来，在美国女性中，人乳头瘤病毒（HPV）相关的肛门癌和口咽癌的发病率有所增加。然而，相对于宫颈癌，非宫颈HPV相关癌症的发病率和负担（年度病例数）趋势仍不清楚。使用2001-2017年美国癌症统计数据集，我们按解剖部位、种族或民族和年龄评估了女性HPV相关癌症的当代发病率趋势和负担（年度病例数）。总体而言，白色女性的宫颈癌发病率趋于稳定，但黑人和西班牙裔女性的宫颈癌发病率继续下降。在65-74岁（2015年为每10万人8.6和8.2）和75岁及以上（2014年为每10万人6.2和6.0）的白色女性中，肛门癌发病率超过宫颈癌发病率。2013年，非宫颈癌负担（n = 11871）超过了宫颈癌负担（n = 11527）。需要制定有效的非宫颈癌筛查策略，并继续改善宫颈癌预防，以防治妇女中的HPV相关癌症。
Human papillomavirus (HPV)-associated anal and oropharyngeal cancer incidence has increased in recent years among US women. However, trends in incidence and burden (annual number of cases) of noncervical HPV-associated cancers relative to cervical cancer remain unclear. Using the 2001-2017 US cancer statistics dataset, we evaluated contemporary incidence trends and burden (annual number of cases) of HPV-associated cancers among women by anatomic site, race or ethnicity, and age. Overall, cervical cancer incidence plateaued among White women but continued to decline among Black and Hispanic women. Anal cancer incidence surpassed cervical cancer incidence among White women aged 65-74 years of age (8.6 and 8.2 per 100 000 in 2015) and 75 years or older (6.2 and 6.0 per 100 000 in 2014). The noncervical cancer burden (n = 11871) surpassed the cervical cancer burden (n = 11527) in 2013. Development of efficacious screening strategies for noncervical cancers and continued improvement in cervical cancer prevention are needed to combat HPV-associated cancers among women.