Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior
Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior
复制标题
DOI：
10.1016/j.neuron.2010.05.011
复制
发表时间：
2010-06-24
期刊：
影响因子：
16.2
通讯作者：
Nakanishi, Shigetada
中科院分区：
文献类型：
--
作者：
Hikida, Takatoshi;Kimura, Kensuke;Nakanishi, Shigetada
在基底神经节中，直接纹状体黑质和间接纹状体苍白通路的会聚输入和多巴胺能调节在奖赏和厌恶学习以及药物成瘾中至关重要。为了探索基底神经节信息是如何通过这两条通路进行加工和整合的，我们开发了一种可逆的神经传递阻断技术，在该技术中，通过特异性表达阻断传递的破伤风毒素以强力霉素依赖的方式选择性地阻断每条通路的传递。结果表明，这两条通路的协调调节是多巴胺介导的急性精神兴奋作用所必需的。然而，这种调节在奖赏学习和可卡因敏化中转变为直接通路的主导作用，在厌恶行为中转变为间接通路的主导作用。因此，这两个途径有不同的作用：直接途径的关键区别联想奖励刺激和非联想的和间接途径的快速记忆形成，以避免厌恶的刺激。
In the basal ganglia, convergent input and dopaminergic modulation of the direct striatonigral and the indirect striatopallidal pathways are critical in rewarding and aversive learning and drug addiction. To explore how the basal ganglia information is processed and integrated through these two pathways, we developed a reversible neurotransmission blocking technique, in which transmission of each pathway was selectively blocked by specific expression of transmission-blocking tetanus toxin in a doxycycline-dependent manner. The results indicated that the coordinated modulation of these two pathways was necessary for dopamine-mediated acute psychostimulant actions. This modulation, however, shifted to the predominant roles of the direct pathway in reward learning and cocaine sensitization and the indirect pathway in aversive behavior. These two pathways thus have distinct roles: the direct pathway critical for distinguishing associative rewarding stimuli from nonassociative ones and the indirect pathway for rapid memory formation to avoid aversive stimuli.