Cerebral Amyloid Angiopathy Is Associated With Executive Dysfunction and Mild Cognitive Impairment
Cerebral Amyloid Angiopathy Is Associated With Executive Dysfunction and Mild Cognitive Impairment
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DOI：
10.1161/strokeaha.116.012999
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发表时间：
2016-08-01
期刊：
影响因子：
8.3
通讯作者：
Smith, Eric E.
中科院分区：
文献类型：
--
作者：
Case, Nevicia F.;Charlton, Anna;Smith, Eric E.
背景和目的尸检研究表明，脑淀粉样血管病（CAA）与认知障碍和痴呆风险相关。我们分析了一项 CAA 患者前瞻性队列研究的神经心理学测试数据，以确定认知障碍的患病率及其与脑磁共振成像特征和载脂蛋白 E 基因型的关联。方法——分析了 34 名 CAA、16 名阿尔茨海默病、69 名轻度认知障碍和 27 名缺血性中风参与者的数据。神经心理学测试结果表示为与测试手册提供的规范数据相关的 z 分数，然后分为记忆、执行功能和处理速度领域。结果 - CAA 参与者的平均测试分数显着低于记忆（-0.44 +/- 1.03；P=0.02）、执行功能（-1.14 +/- 1.07；P）的标准。
Background and Purpose-Autopsy studies suggest that cerebral amyloid angiopathy (CAA) is associated with cognitive impairment and risk for dementia. We analyzed neuropsychological test data from a prospective cohort study of patients with CAA to identify the prevalence of cognitive impairment and its associations with brain magnetic resonance imaging features and the apolipoprotein E genotype.Methods-Data were analyzed from 34 CAA, 16 Alzheimer's disease, 69 mild cognitive impairment, and 27 ischemic stroke participants. Neuropsychological test results were expressed as z scores in relation to normative data provided by the test manuals and then grouped into domains of memory, executive function, and processing speed.Results-Mean test scores in CAA participants were significantly lower than norms for memory (-0.44 +/- 1.03; P=0.02), executive function (-1.14 +/- 1.07; P