ApoE-ε4 is associated with reduced memory in long-standing intractable temporal lobe epilepsy
ApoE-ε4 is associated with reduced memory in long-standing intractable temporal lobe epilepsy
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DOI：
10.1212/01.wnl.0000253021.60887.db
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发表时间：
2007-02-06
期刊：
影响因子：
9.9
通讯作者：
Diaz-Arrastia, R.
中科院分区：
文献类型：
--
作者：
Busch, R. M.;Lineweaver, T. T.;Diaz-Arrastia, R.
目的：探讨难治性颞叶癫痫（TLE）行颞叶切除术患者载脂蛋白（ApoE） epsilon 4等位基因与记忆表现（言语和非言语）的关系。方法：对87例成年TLE患者（epsilon 4 = 22，非epsilon 4 = 65）进行术前和术后记忆功能检测，以确定ApoE-epsilon 4的表达是否与该人群的记忆功能相关，并研究这种关系如何受癫痫持续时间的影响。结果：ApoE-epsilon 4水平与癫痫持续时间之间存在显著的相互作用，癫痫持续时间长的epsilon 4携带者在言语和非言语测试中表现出最差的记忆表现。这种关系在颞叶切除术之前和之后都观察到了，随着时间的推移，测试表现几乎没有变化。结论：ApoE-epsilon 4等位基因与长期癫痫发作相互作用，影响医学上难治性颞叶癫痫患者的语言和非语言记忆表现。
Objective: To investigate the relationship between the apolipoprotein (ApoE) epsilon 4 allele and memory performance ( verbal and nonverbal) in patients with medically intractable temporal lobe epilepsy (TLE) who underwent temporal lobectomy. Methods: Presurgical and postsurgical memory performance was examined in 87 adult patients with TLE (epsilon 4 = 22; non-epsilon 4 = 65) to determine whether the expression of ApoE-epsilon 4 may be associated with memory performance in this population and to examine how this relationship may be affected by duration of epilepsy. Results: There was a significant interaction between ApoE-epsilon 4 status and duration of epilepsy such that epsilon 4 carriers with a long duration of epilepsy demonstrated the poorest memory performance on both verbal and nonverbal measures. This relationship was observed both before and after temporal lobectomy, with little change in test performance over time. Conclusions: The ApoE-epsilon 4 allele interacts with longstanding seizures to affect memory performance, both verbal and nonverbal, in patients with medically intractable temporal lobe epilepsy.