Highly sensitive lens culinaris agglutinin-reactive α-fetoprotein is useful for early detection of hepatocellular carcinoma in patients with chronic liver disease
Highly sensitive lens culinaris agglutinin-reactive α-fetoprotein is useful for early detection of hepatocellular carcinoma in patients with chronic liver disease
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DOI：
10.3892/or.2011.1425
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发表时间：
2011-11-01
期刊：
影响因子：
4.2
通讯作者：
Tsubouchi, Hirohito
中科院分区：
文献类型：
--
作者：
Oda, Kohei;Ido, Akio;Tsubouchi, Hirohito
甲胎蛋白岩藻糖基化部分（AFP-L3）是肝细胞癌（HCC）的特异性标志物。然而，传统的AFP-L3%（c-AFP-L3%）在血清甲胎蛋白（AFP）水平低的情况下并不总是可靠的。在这项研究中，我们评估了一种新开发的检测方法，高灵敏度AFP-L3%（hs-AFP-L3%）的临床实用性。受试者包括74例良性肝病（BLD）患者，包括慢性肝炎和肝硬化，以及94例HCC患者。在早期HCC患者（单发或单发）中，血清hs-AFP-L3%显著高于c-AFP-L3%。
The fucosylated fraction of alpha-fetoprotein (AFP-L3) is a specific marker for hepatocellular carcinoma (HCC). However, conventional AFP-L3% (c-AFP-L3%) has not always been reliable in cases with low serum alpha-fetoprotein (AFP) levels. In this study, we evaluated the clinical utility of a newly developed assay, highly sensitive AFP-L3% (hs-AFP-L3%). Subjects included 74 patients with benign liver disease (BLD), including chronic hepatitis and cirrhosis, and 94 with HCC. Serum hs-AFP-L3% was significantly higher than c-AFP-L3% in patients with early-stage HCC (solitary or