CT-guided radiofrequency ablation for lung cancer
CT-guided radiofrequency ablation for lung cancer
复制标题
CT引导下肺癌射频消融术
DOI：
10.1007/s10147-007-0665-y
复制
发表时间：
2007
影响因子：
3.3
通讯作者：
T. Okuma
中科院分区：
文献类型：
--
作者：
T. Matsuoka;T. Okuma
最近，经皮射频（RF）消融越来越多地作为肺部恶性肿瘤的局部治疗方法进行。在射频消融中，射频的应用会搅动电极周围组织中的离子，导致它们高速波动，从而产生摩擦热。产生的热量使组织凝固。穿刺是在计算机断层扫描（CT）引导下进行的，方式与针吸活检相同。在动物研究中，推测空气起到了绝缘体的作用，并且热量不会在很大程度上损害周围正常的肺实质，因为肺充满了空气。兔子实验性 VX2 肿瘤通过射频消融得到了很好的控制。自 2000 年首次报道射频消融临床用于肺部恶性肿瘤以来，已经发表了许多系列文章。这些研究中报告的患者不适合手术治疗，要么是因为心肺功能不佳和合并症，要么是因为他们拒绝手术。通过射频消融，直径为 3 厘米或更小的肿瘤预计会完全坏死。姑息性射频消融可能适用于大肿瘤。与穿刺相关的最常见并发症是气胸，与针吸活检相比，射频消融的发生率更高。初步结果令人鼓舞，但我们等待未来的长期结果报告。
Recently, percutaneous radiofrequency (RF) ablation has been increasingly performed as a local treatment for lung malignancies. In RF ablation, the application of radiofrequency agitates ions in the tissues surrounding the electrode, causing them to fluctuate at high speed, and this generates frictional heat. The generated heat coagulates the tissues. Puncture is carried out under computed tomography (CT) guidance in the same manner as that for needle biopsy. In animal studies, it was speculated that air functioned as an insulator and that the heat did not damage normal surrounding lung parenchyma to any great extent, because lung is filled with air. An experimental VX2 tumor in rabbits was well controlled by RF ablation. Since the clinical use of RF ablation for lung malignancies was first reported in 2000, many series have been published. The patients reported in these studies were not candidates for surgical treatment, either because of poor cardiopulmonary function and comorbidities, or because they refused surgery. With RF ablation, complete necrosis can be expected for tumors with a diameter of 3 cm or less. Palliative RF ablation may be indicated for large tumors. The most frequent complication associated with puncture was pneumothorax, with a frequency higher for RF ablation compared with that for needle biopsy. The initial results have been promising, but we await future reports for long-term results.
MRI 引导的正常肺组织射频热消融：兔模型体内研究。
DOI：
10.2214/ajr.183.3.1830599
发表时间：
2004
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Wacker,FrankK;Nour,SherifG;Eisenberg,Rosana;Duerk,JeffreyL;Lewin,JonathanS
通讯作者：
Lewin,JonathanS