14-3-3 Proteins: a window for a deeper understanding of fungal metabolism and development
14-3-3 Proteins: a window for a deeper understanding of fungal metabolism and development
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14-3-3 蛋白质：深入了解真菌代谢和发育的窗口
DOI：
10.1007/s11274-019-2597-x
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发表时间：
2019
影响因子：
4.1
通讯作者：
Zhao Mingwen
中科院分区：
文献类型：
--
作者：
Shi Liang;Ren Ang;Zhu Jing;Yu Hanshou;Jiang Ailiang;Zheng Huihua;Zhao Mingwen
14-3-3蛋白的异构体，与其在哺乳动物和植物中高度保守的同源物相似，在转录和功能上都受到细胞外和细胞内环境的影响。这些蛋白与磷酸化的客户蛋白结合以调节其在真菌中的功能。由于磷酸化调节了生物体中大量不同的生理反应，14-3-3蛋白在多种生理功能中发挥作用，包括控制代谢、细胞分裂和对环境刺激的反应。这些蛋白质还可以调节信号通路，转导来自环境的输入和引起生理反应的下游蛋白质。越来越多的证据支持14-3-3蛋白在调节各个水平的发育和代谢中的突出作用。本文首先对14-3-3蛋白的分子结构作一综述。其次，我们讨论了14-3-3蛋白在发育和代谢调节中的潜在作用。第三，我们回顾了14-3-3蛋白在调节其结合伙伴（包括受体、蛋白激酶和一些蛋白激酶底物）中的作用。最后，本文回顾了最近的研究进展，进一步阐明了14-3-3蛋白在响应环境应激的信号转导中的作用。
Isoforms of 14-3-3 proteins, similar to their highly conserved homologs in mammals and plants, are both transcriptionally and functionally affected by their extracellular and intracellular environments. These proteins bind to phosphorylated client proteins to modulate their functions in fungi. Since phosphorylation regulates a plethora of different physiological responses in organisms, 14-3-3 proteins play roles in multiple physiological functions, including those controlling metabolisms, cell division, and responses to environmental stimulation. These proteins could also modulate signaling pathways that transduce inputs from the environment and downstream proteins that elicit physiological responses. Increasing evidence supports a prominent role for 14-3-3 proteins in regulating development and metabolism at various levels. In this review, we first provide a brief summary of the molecular structure of 14-3-3 proteins. Second, we discuss the potential roles of 14-3-3 proteins in the regulation of development and metabolism. Third, we review the roles of 14-3-3 proteins in the regulation of their binding partners, including receptors, protein kinases, and some protein kinase substrates. Finally, this review examines recent advances that further elucidate the role of 14-3-3 proteins in signaling transduction in response to environmental stress.