Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration.
Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration.
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DOI：
10.2174/1574888x10666150113112149
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发表时间：
2015
影响因子：
2.7
通讯作者：
Risbud MV
中科院分区：
文献类型：
--
作者：
Choi H;Johnson ZI;Risbud MV
椎间盘（IVD）退变和相关腰痛（LBP）仍然是我们社会的一个主要负担，在治疗策略和患者生活质量方面没有显著改善。虽然最近用于治疗退行性椎间盘疾病的细胞移植研究显示出有希望的结果，但为了更好地评估这些疗法的成功和功能结果，了解移植细胞是否能产生健康的髓核（NP）组织是至关重要的。NP细胞表型是独特的，由一组特征标记的表达来定义，这些标记反映了它们的特殊生理和功能。本文综述了反映NP细胞及其祖细胞独特生理和功能的表型标记物，这些标记物应被考虑用于衡量细胞治疗椎间盘退变的结果。
Intervertebral disc (IVD) degeneration and associated low back pain (LBP) remains a major burden to our society without a significant improvement in treatment strategies or patient’s quality of life. While the recent cell-transplantation studies for treatment of degenerative disc disease showed promising results, to better gauge the success and functional outcomes of these therapies, it is crucial to understand if transplanted cells give rise to healthy nucleus pulposus (NP) tissue. NP cell phenotype is unique and is defined by expression of a characteristic set of markers that reflect their specialized physiology and function. This review summarizes phenotypic markers that mirror unique physiology and function of NP cells and their progenitors and should be considered to measure outcomes of cell-based therapies to treat disc degeneration.