Comparison of Oral and Parenteral Iron Administration on Iron Homeostasis, Oxidative and Immune Status in Anemic Neonatal Pigs
Comparison of Oral and Parenteral Iron Administration on Iron Homeostasis, Oxidative and Immune Status in Anemic Neonatal Pigs
复制标题
口服和肠外铁剂对贫血新生猪铁稳态、氧化和免疫状态的比较
DOI：
10.1007/s12011-019-01846-9
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发表时间：
2020-05-01
影响因子：
3.9
通讯作者：
Yin, Yulong
中科院分区：
文献类型：
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作者：
Dong, Zhenglin;Wan, Dan;Yin, Yulong
本研究旨在评估口服和肠外铁剂给药中铁状态对预防缺铁性贫血的影响。 24头1日龄雄性新生仔猪分为3组，分别给予不补铁（NON）、肌肉注射右旋糖酐铁（FeDex）和口服甘氨酸亚铁螯合物（FeGly）。第8天时，三组的最终体重、平均增重和组织系数均无显着差异（P>0.05）。口服FeGly和FeDex注射液均显着增加血清铁、铁蛋白、血红蛋白和组织铁沉积（P< 0.05）。然而，注射 FeDex 补充剂导致铁调素水平和肝铁沉积迅速升高（P< 0.05）。此外，与肠外补铁仔猪相比，口服铁剂仔猪血清IgA水平、SOD、GSH-Px活性较高，肝脏IL-1β、TNF-α表达较低，脾脏IL-6、TNF-α表达较低（P<0.05）。根据我们的结果，口服甘氨酸亚铁螯合物可以改善贫血新生猪的铁稳态以及氧化和免疫状态。
The present study was to evaluate the consequences of iron status across oral and parenteral iron administrations in prevention of iron deficiency anemia. A total of 24 one-day-old male neonatal piglets were allocated into three groups given non-iron supplementation (NON), intramuscular iron dextran injection (FeDex), and oral administration of ferrous glycine chelate (FeGly), respectively. At day 8, no significant differences in final body weight, average weight gain, and tissue coefficients were observed among three groups (P> 0.05). Both oral FeGly and FeDex injection significantly increased serum iron, ferritin, hemoglobin, and tissue iron deposition (P< 0.05). However, FeDex-injected supplementation resulted in rapidly rising hepcidin levels and hepatic iron deposition (P< 0.05). In addition, compared to parenteral iron supplementation, greater serum IgA level, SOD, and GSH-Px activities, lower expressions ofIL-1βandTNF-αin the liver, and lower expressions ofIL-6andTNF-αin the spleen were found in oral iron piglets (P< 0.05). According to our results, oral administration of ferrous glycine chelate improved iron homeostasis, and oxidative and immune status in anemic neonatal pigs.