Complete sequence of echovirus 23 and its relationship to echovirus 22 and other human enteroviruses
Complete sequence of echovirus 23 and its relationship to echovirus 22 and other human enteroviruses
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DOI：
10.1016/s0168-1702(98)00080-x
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发表时间：
1998-08-01
期刊：
影响因子：
5
通讯作者：
Pallansch, MA
中科院分区：
文献类型：
--
作者：
Oberste, MS;Maher, K;Pallansch, MA
为了确定埃可病毒 23 (E23) 和其他人类肠道病毒之间的关系，我们测定了 1986 年从康涅狄格州一名高烧儿童身上分离出来的 E23 病毒株的完整核苷酸序列，并将核苷酸序列和推导的氨基酸序列与代表每个主要肠道病毒系统发育群的其他肠道病毒（脊髓灰质炎病毒 1 型、柯萨奇病毒 A16、柯萨奇病毒 B3、艾可病毒 22 (E22) 和肠道病毒 70。E23（CT86-6760 株）的基因组长度为 7352 个核苷酸，不包括多聚腺苷酸尾，其基因组组织是典型的小核糖核酸病毒。核苷酸序列和推导的氨基酸序列与E22病毒最相关，E23与E22病毒具有许多相同的生物学特性，并且与其他肠道病毒的序列有很大不同（平均氨基酸序列同一性<20%）。这些数据进一步支持了以下观点：E22 和 E23 与肠道病毒属的成员不同，并且应将它们重新分类为小核糖核酸病毒科内的单独属。 (C) 1998 Elsevier Science B.V. 保留所有权利。
To define the relationship between echovirus 23 (E23) and other human enteroviruses, we have determined the complete nucleotide sequence of a strain of E23 isolated from a child with high fever in Connecticut in 1986 and compared the nucleotide and deduced amino acid sequences with those of other enteroviruses representing each of the major enterovirus phylogenetic groups, poliovirus type 1, coxsackievirus A16, coxsackievirus B3, echovirus 22 (E22), and enterovirus 70. The genome of E23 (strain CT86-6760) was 7352 nucleotides in length, exclusive of the poly(A) tail, and the genome organization was typical of the picornaviruses. The nucleotide sequence and deduced amino acid sequences were most related to those of E22, a virus with which E23 shares many biological properties, and was quite divergent from the sequences of other enteroviruses ( < 20% average amino sequence identity). These data lend further support to the suggestion that E22 and E23 are distinct from members of the Enterovirus genus and that they should be reclassified in a separate genus within the Picornaviridae. (C) 1998 Elsevier Science B.V. All rights reserved.