Autonomic dysfunction in autoimmune rheumatic disease
Autonomic dysfunction in autoimmune rheumatic disease
复制标题
DOI：
10.1016/j.autrev.2009.01.018
复制
发表时间：
2009-06-01
影响因子：
13.6
通讯作者：
Stojanovich, Ljudmila
中科院分区：
文献类型：
--
作者：
Stojanovich, Ljudmila
已知自身免疫性风湿病（ARD）患者会出现心血管和神经系统表现，通常为亚临床形式。术语自主神经系统（ANS）描述了主要与身体功能调节有关的神经。它由交感神经和副交感神经组成，它们的功能是互补的。ANS参与很少在ARD患者中进行研究，研究显示了相互矛盾的结果。这可能是因为自主神经功能障碍的症状是非特异性的，并且变化极大，并且可能涉及几个系统，如胃肠，心血管和神经。此外，检测自主神经功能障碍的测试在临床流变学实践中并不常规使用。另一个困难是区分药物的心血管效应与ARD的参与。以前关于这一主题的研究发现，在自身免疫性疾病患者中，副交感神经和交感神经功能障碍的比例各不相同，根据所使用的方法，各种测试的比例在24%至100%之间。心血管自主神经功能障碍是最常见的ANS功能障碍类型，并且在大多数ARD患者中被发现。(C)2009 Elsevier B.V.保留所有权利。
Cardiovascular and neurological manifestations are known to occur in patients with autoimmune rheumatic disease (ARD), often in subclinical form. The term autonomic nervous system (ANS) describes nerves that are concerned predominantly with the regulation of bodily functions. It is comprised of sympathetic and parasympathetic nerves, and their function is complementary. ANS involvement has rarely been studied in patients with ARD, and studies have shown conflicting results. This may be because symptoms of autonomic dysfunction are nonspecific and extremely varied, and may pertain to several systems like the gastrointestinal, cardiovascular, and nervous. Moreover, tests to detect autonomic dysfunction are not routinely employed in clinical rheumatological practice. Another difficulty is to differentiate cardiovascular effects of drugs from ARD involvement. Previous studies on this topic found signs of parasympathetic and sympathetic dysfunction in variable proportions in patients with autoimmune diseases, between 24% and 100% in various tests depending on the methods used. Cardiovascular autonomic dysfunction is the most common type of ANS dysfunction, and was revealed in the majority of ARD patients. (C) 2009 Elsevier B.V. All rights reserved.