Relationship Between the Reciprocal Change in Inflammation-Related Biomarkers (Fibrinogen-to-Albumin and hsCRP-to-Albumin Ratios) and the Presence and Severity of Coronary Slow Flow
Relationship Between the Reciprocal Change in Inflammation-Related Biomarkers (Fibrinogen-to-Albumin and hsCRP-to-Albumin Ratios) and the Presence and Severity of Coronary Slow Flow
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DOI：
10.1177/1076029619835383
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发表时间：
2019-03-11
影响因子：
2.9
通讯作者：
Kaya, Adnan
中科院分区：
文献类型：
--
作者：
Kayapinar, Osman;Ozde, Cem;Kaya, Adnan
炎症与内皮功能障碍、动脉粥样硬化和微血管冠状动脉功能障碍的发病机制有关。在这种情况下，它被认为是纤维蛋白原，高敏C反应蛋白（hsCRP），白蛋白可能与冠状动脉慢血流（CSF）的发病机制。我们的目的是评估与冠状动脉造影正常和稳定性冠状动脉疾病（CAD）患者相比，CSF患者的纤维蛋白原与白蛋白和hsCRP与白蛋白的比值。共纳入65例CSF患者、65例新诊断的稳定型CAD患者和65例冠状动脉造影正常的对照参与者。采用心肌梗死溶栓帧计数法测定冠脉血流速度。分析所有患者的纤维蛋白原、hsCRP和白蛋白水平，并计算纤维蛋白原与白蛋白和hsCRP与白蛋白的比值。3组的基线特征相似。与对照组相比，CSF和CAD组的血浆白蛋白水平显著降低，而纤维蛋白原和hsCRP水平显著升高。与对照组相比，CSF组和CAD组的纤维蛋白原与白蛋白和hsCRP与白蛋白比值均显著较高。在整个研究人群中，hsCRP与白蛋白比值与心肌梗死溶栓治疗的平均帧数呈正相关。根据受试者操作特征分析，纤维蛋白原/白蛋白和hsCRP/白蛋白比值预测CSF的有效性是显著的。纤维蛋白原与白蛋白和hsCRP与白蛋白的比值呈相反变化，表明炎症可能在CSF的发病机制中发挥作用。
Inflammation has been implicated in the pathogenesis of endothelial dysfunction, atherosclerosis, and microvascular coronary dysfunction. In this context, it is thought that fibrinogen, high-sensitive C-reactive protein (hsCRP), and albumin may be associated with the pathogenesis of coronary slow flow (CSF). We aimed to evaluate the ratios of fibrinogen-to-albumin and hsCRP-to-albumin in patients with CSF compared to patients with angiographically normal coronary arteries and stable coronary artery disease (CAD). In all, 65 patients with CSF, 65 patients with newly diagnosed stable CAD, and 65 control participants with angiographically normal coronary arteries were included. The coronary flow rates of all patients were determined by the Thrombolysis in Myocardial Infarction frame count method. Fibrinogen, hsCRP, and albumin levels were analyzed in all patients, and the fibrinogen-to-albumin and hsCRP-to-albumin ratios were calculated. The baseline characteristics of the 3 groups were similar. The plasma albumin level was significantly lower, whereas the fibrinogen and the hsCRP levels were significantly higher, in the CSF and CAD groups compared to the controls. The fibrinogen-to-albumin and hsCRP-to-albumin ratios were significantly higher in both the CSF and the CAD groups compared to the control group. The hsCRP-to-albumin ratio was positively correlated with the mean Thrombolysis in Myocardial Infarction frame count in the whole study population. According to the receiver-operating characteristic analysis, the efficacies of the fibrinogen-to-albumin and hsCRP-to-albumin ratios in predicting CSF were significant. The fibrinogen-to-albumin and hsCRP-to-albumin ratios, which were increased by a reciprocal change, suggest that inflammation may play a role in the pathogenesis of CSF.