Disorders of Pubertal Development
Disorders of Pubertal Development
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DOI：
10.3238/arztebl.2009.0295
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发表时间：
2009-04-24
影响因子：
7.7
通讯作者：
Duebbers, Angelika
中科院分区：
文献类型：
--
作者：
Braemswig, Juergen;Duebbers, Angelika
背景：青春期是青春期生理和心理社会发育的一个极其重要的阶段。方法：选择文献综述。结果：青春期异常的诊断需要透彻了解青春期正常发育和正常青春期的变异及其病理。根据定义，正常青春期发育的变异发生的频率大约为3%。详细的病史是对正常变异或异常青春期进行诊断评估的第一步。进一步的评估包括实验室测试(雌二醇、睾酮和GnRH测试结果等)和成像研究(左手和手腕X光、性腺超声检查、磁共振成像)。治疗既针对青春期发育早熟、明显延迟或缺失的急性和长期后果。结论：青春期发育障碍应及早认识，由儿科内分泌科医生正确诊断，并给予适当治疗。Dtsch Arztebl Int 2009；106(17)：295-304 DOI：10.3238/arztebl.2009.0295
Background: Puberty is an extremely important phase in the physical and psychosocial development of the adolescent.Methods: Selective literature review.Results: The diagnosis of abnormal puberty requires thorough knowledge of normal pubertal development and of the variations of normal puberty as well as its pathology. Variations of normal pubertal development can be expected, by definition, to occur at a frequency of roughly 3%. A detailed history is the first step in the diagnostic evaluation of a normal variant or an abnormal puberty. Further evaluation includes laboratory testing (estradiol, testosterone, and the results of a GnRH test, among others) and imaging studies (x-ray of the left hand and wrist, ultrasonography of the gonads, magnetic resonance imaging). Treatment is directed at both the acute and the long-term consequences of precocious, markedly delayed, or absent pubertal development.Conclusions: Disorders of pubertal development should be recognized early, correctly diagnosed by a pediatric endocrinologist, and appropriately treated. Dtsch Arztebl Int 2009; 106(17): 295-304 DOI: 10.3238/arztebl.2009.0295