A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers.
A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers.
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DOI：
10.1186/s12951-023-01995-z
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发表时间：
2023-08-29
影响因子：
10.2
通讯作者：
Wang, Lei
中科院分区：
文献类型：
--
作者：
Song, Qingling;Yang, Junfei;Wu, Xiaocui;Li, Yao;Zhao, Hongjuan;Feng, Qianhua;Zhang, Zhenzhong;Zhang, Yun;Wang, Lei
生物屏障严重制约了口服给药系统在疾病治疗中的有效反应。由于复杂的胃肠道环境要求载体具有不同的甚至矛盾的性质，利用基于单一构造手段的载体很难同时克服这些障碍。有趣的是，孢子衣壳融合了许多独特的生物学特性，如高抵抗力、良好的稳定性等。这一事实为构建基于SC的多功能口腔纳米平台提供了无限的灵感来源。在此，我们开发了一种仿生孢子纳米平台(SC@DS NPs)，以成功地克服口腔生物障碍。首先，将阿霉素(DOX)和索拉非尼(SOR)自组装成无载体纳米粒(DS NPs)。随后，SC可以有效地从益生菌孢子中分离出来，并作为运送DS NPs的功能载体。不出所料，Sc@DS纳米粒口服后可以有效地通过崎岖的胃环境，并进一步转运到肠道。令人惊讶的是，我们发现SC@DS纳米粒在粘液穿透和跨皮运输方面表现出显著的改善，这与SC的蛋白质种类有关。本研究表明，SC@DS纳米粒能有效克服多种生物屏障，提高治疗效果。网上版载有补充材料，可在10.1186/s12951-023-01995-z查阅。
The biological barriers have seriously restricted the efficacious responses of oral delivery system in diseases treatment. Utilizing a carrier based on the single construction means is hard to overcome these obstacles simultaneously because the complex gastrointestinal tract environment requires carrier to have different or even contradictory properties. Interestingly, spore capsid (SC) integrates many unique biological characteristics, such as high resistance, good stability etc. This fact offers a boundless source of inspiration for the construction of multi-functional oral nanoplatform based on SC without further modification. Herein, we develop a type of biomimetic spore nanoplatform (SC@DS NPs) to successively overcome oral biological barriers. Firstly, doxorubicin (DOX) and sorafenib (SOR) are self-assembled to form carrier-free nanoparticles (DS NPs). Subsequently, SC is effectively separated from probiotic spores and served as a functional vehicle for delivering DS NPs. As expect, SC@DS NPs can efficaciously pass through the rugged stomach environment after oral administration and further be transported to the intestine. Surprisingly, we find that SC@DS NPs exhibit a significant improvement in the aspects of mucus penetration and transepithelial transport, which is related to the protein species of SC. This study demonstrates that SC@DS NPs can efficiently overcome multiple biological barriers and improve the therapeutic effect. The online version contains supplementary material available at 10.1186/s12951-023-01995-z.
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