The Cutaneous Lupus Erythematosus Disease Activity and Severity Index: Expansion for rheumatology and dermatology
The Cutaneous Lupus Erythematosus Disease Activity and Severity Index: Expansion for rheumatology and dermatology
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DOI：
10.1002/art.23319
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发表时间：
2008-03-15
期刊：
影响因子：
--
通讯作者：
Werth, V. P.
中科院分区：
文献类型：
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作者：
Krathen, M. S.;Dunham, J.;Werth, V. P.
Objective.评估皮肤红斑狼疮疾病面积和严重程度指数（CLASI）的有效性，通过可靠性测试，皮肤科医生使用，并扩展验证。14名患有皮肤红斑狼疮（CLE; n = 10）、单纯模仿性皮肤病（临床表现与CLE相似的皮肤病变; n = 1）或两者（n = 3）的受试者由学术皮肤科医生（n = 5）和风湿科医生（n = 5）使用CLASI进行评定。皮肤病学组内相关系数（ICC）为0.92的活动和0.82的损害;风湿病学的ICC为0.83的活动和0.86的损害。对于内部可靠性，皮肤科斯皮尔曼的rho为0.94的活动和0.97的损害;对于流变学的斯皮尔曼的rho为0.91的活动和0.99的损害。我们的数据证实了CLASI在皮肤科医生使用时的可靠性，并支持CLASI作为一种可靠的仪器供风湿科医生使用。
Objective. To evaluate the validity of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) for use by rheumatologists via reliability testing, and to extend the validation for dermatologists.Methods. Fourteen subjects with cutaneous lupus erythematosus (CLE; n = 10), a mimicker skin disease only (a cutaneous lesion that may appear clinically similar to CLE; n = 1), or both (n = 3) were rated with the CLASI by academic-based dermatologists (n = 5) and rheumatologists (n = 5).Results. The dermatology intraclass correlation coefficient (ICC) was 0.92 for activity and 0.82 for damage; for rheumatology the ICC was 0.83 for activity and 0.86 for damage. For intrarater reliability, the dermatology Spearman's rho was 0.94 for activity and 0.97 for damage; for rheumatology the Spearman's rho was 0.91 for activity and 0.99 for damage.Conclusion. Our data confirm the reliability of the CLASI when used by dermatologists and support the CLASI as a reliable instrument for use by rheumatologists.