Gastric infection by Helicobacter pylori.
Gastric infection by Helicobacter pylori.
复制标题
幽门螺杆菌的胃感染。
DOI：
10.1007/s11894-011-0226-4
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发表时间：
2011-12
影响因子：
--
通讯作者：
Wen Y
中科院分区：
文献类型：
--
作者：
Sachs G;Scott DR;Wen Y
幽门螺杆菌感染了世界上一半的人口，并在溃疡病和胃癌中起着因果作用。这种致病性嗜中性菌通过酸适应过程独特地定殖于酸性胃环境。酸适应是生物体在酸性环境中维持周质pH接近中性以防止细胞质pH下降以维持在酸中的活力和生长的能力。近年来，由于耐药性的增加，H。幽门螺杆菌根除率已经下降到80%以下，这重新引起了人们对新的根除方案和目标的兴趣。本文就H.幽门和酸适应，各种检测程序，抗生素耐药性和胃酸在生物体对目前使用的抗生素的敏感性中所起的作用，并提出了几种新的药物靶点，这些药物靶点将在没有抗生素的情况下促进根除。
Helicobacter pylori infects half of the world’s population and plays a causal role in ulcer disease and gastric cancer. This pathogenic neutralophile uniquely colonizes the acidic gastric milieu through the process of acid acclimation. Acid acclimation is the ability of the organism to maintain periplasmic pH near neutrality in an acidic environment to prevent a fall in cytoplasmic pH in order to maintain viability and growth in acid. Recently, due to an increase in antibiotic resistance, the rate of H. pylori eradication has fallen below 80% generating renewed interest in novel eradication regimens and targets. In this article, we review the gastric biology of H. pylori and acid acclimation, various detection procedures, antibiotic resistance and the role that gastric acidity plays in the susceptibility of the organism to antibiotics currently in use and propose several novel drug targets that would promote eradication in the absence of antibiotics.