INFLUENCE OF PERSISTENT OBESITY IN CHILDREN ON CARDIOVASCULAR RISK-FACTORS - THE BOGALUSA HEART-STUDY
INFLUENCE OF PERSISTENT OBESITY IN CHILDREN ON CARDIOVASCULAR RISK-FACTORS - THE BOGALUSA HEART-STUDY
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DOI：
10.1161/01.cir.69.5.895
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发表时间：
1984-01-01
期刊：
影响因子：
37.8
通讯作者：
BERENSON, GS
中科院分区：
文献类型：
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作者：
ARISTIMUNO, GG;FOSTER, TA;BERENSON, GS
对1973年、1976年和1978年检查的2230名儿童的体脂指数、血脂和脂蛋白水平与血压之间的关系进行了研究。这些儿童被分组，使用7个百分位数（P）的间隔三头肌皮褶厚度，具体的种族，性别和年龄;心血管危险因素变量进行了评估，随着时间的推移。在最初处于最低P组（<15 P）的238名儿童中，44%保持在那里，65%的皮褶厚度在3次低于30 P。在最高P组的352名儿童中（≥ 100），85 P），被认为是非常肥胖的人，39%保持在这个水平，而69%保持在70 P或更高。在366名被认为肥胖的人中，70，<89 P），38%保持在70 P或以上。在基线时，7个组中的儿童在体重、重量（wt/ht 3）、收缩压和舒张压、血清甘油三酯水平和前β-淀粉样蛋白水平方面不同。和β-脂蛋白胆固醇水平。将来自其他6个组中的每一个组的儿童的数据与来自中间范围（≥ 10）的儿童的数据进行成对比较。肥胖组和极肥胖组收缩压显著高于对照组（P < 0.05），而舒张压仅P值最高组显著高于对照组（P < 0.05）。这些差异随着时间的推移而增加和分化。在肥胖和非常肥胖组中，随着时间的推移，脂蛋白胆固醇水平，以及前-β-脂蛋白胆固醇水平和收缩压。最低和中等范围组的甘油三酯水平随着时间的推移而下降，但在肥胖和非常肥胖的儿童中仍保持在较高水平。有一个强烈的趋势跟踪（随着时间的推移，在同一P组）在瘦，肥胖和非常肥胖的儿童。与中等范围组相比，追踪组在基线水平和随时间推移的风险因素变量中显示出明确的差异。由于在生命早期持续肥胖会增加心血管疾病的风险，因此随着时间的推移测量儿童的皮褶厚度是检测成人心血管疾病的潜在可能性的有用方法。
The relationship between body fat indexes, lipid and lipoprotein levels, and blood pressure was studied in 2230 children, each examined during 1973, 1976 and 1978. The children were grouped with the use of 7 percentile (P) intervals of triceps skinfold thickness that were specific for race, sex and age; cardiovascular risk factor variables were assessed over time. Of the 238 children initially in the lowest P group (< 15P), 44% remained there and 65% had skinfold thicknesses below 30P on the 3 occasions. Of the 352 children in the highest P group (.gtoreq. 85P), who were considered to be very obese, 39% remained at this level, while 69% remained at 70P or greater. Of the 366 considered to be obese, (.gtoreq. 70, < 89P), 38% remained at or above 70P. At baseline, children in the 7 groups differed in weight, ponderosity (wt/ht3), systolic and diastolic blood pressures, serum triglyceride levels and pre-.beta.- and .beta.-lipoprotein cholesterol levels. Pairwise comparison of data from children in each of the 6 other groups with those from children in the middle range (.gtoreq. 40, < 60P) showed that the obese and very obese children had significantly higher systolic blood pressures (P < 0.05), while only those in the highest P group had significantly greater diastolic blood pressures (P < 0.05). These differences increased and diverged over time. Those in the obese and very obese groups showed a striking drop over time in .alpha.-lipoprotein cholesterol levels, and increases in pre-.beta.-lipoprotein cholesterol levels, and systolic blood pressure. Triglyceride levels decreased over time for the lowest and middle range groups, but remained at higher levels in obese and very obese children. There was a strong tendency for tracking (remaining in the same P group over time) in lean, obese and very obese children. Those who tracked showed definite differences in risk factor variables at the baseline level and over time when compared with the middle range group. Since consistent obesity in early life enhances cardiovascular risk, the measurement over time of skinfold thickness in children is a useful method to detect the potential for adult cardiovascular disease.