Radiotherapy and Immune Checkpoint Blockade for Melanoma: A Promising Combinatorial Strategy in Need of Further Investigation.
Radiotherapy and Immune Checkpoint Blockade for Melanoma: A Promising Combinatorial Strategy in Need of Further Investigation.
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DOI：
10.1097/ppo.0000000000000236
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Barker CA
中科院分区：
文献类型：
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作者：
Escorcia FE;Postow MA;Barker CA
放射治疗和免疫检查点阻断是黑色素瘤的有效治疗方法。最近的临床前研究表明放疗和免疫检查点阻断的相互作用。回顾性临床研究，以及少量的前瞻性研究已经进行了探索这种相互作用的黑色素瘤患者。在这篇综述中，我们介绍了放射治疗和免疫检查点阻断相结合的临床研究结果，并得出结论，这是一个值得进一步研究的有前途的策略。
Radiotherapy and immune checkpoint blockade are effective treatments for melanoma. Recent preclinical studies have suggested an interaction of radiotherapy and immune checkpoint blockade. Retrospective clinical studies, as well as a small number of prospective studies have been undertaken to explore this interaction in patients with melanoma. In this review, we present the results of clinical studies combining radiotherapy and immune checkpoint blockade and conclude that this is a promising strategy worth of further investigation.