Amygdala kindling of forebrain seizures and the occurrence of brainstem seizures in genetically epilepsy-prone rats
Amygdala kindling of forebrain seizures and the occurrence of brainstem seizures in genetically epilepsy-prone rats
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DOI：
10.1111/j.1528-1157.1996.tb00011.x
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发表时间：
1996-02-01
期刊：
影响因子：
5.6
通讯作者：
Jobe, PC
中科院分区：
文献类型：
--
作者：
Coffey, LL;Reith, MEA;Jobe, PC
每日对大鼠的杏仁核进行电刺激会引起前脑癫痫发作。遗传性癫痫易感大鼠在听源性癫痫（AGS）筛查（“脑干癫痫经历”）中癫痫发作严重程度评分为9分（GEPR-9s），与对照大鼠相比，需要更少的刺激才能实现完全点燃的癫痫发作（前肢直立和跌倒时的阵挛）。AGS-naive gepr -9需要中等数量的刺激，这表明遗传易感性和先前的声诱发脑干癫痫发作经历都有作用。其他前脑诱发指标，如放电后阈值/持续时间和癫痫发作潜伏期/持续时间，也涉及遗传和表型（既往癫痫发作经历）因素。在两组的大多数gepr -9患者中，前脑刺激后发生严重的脑干癫痫发作。脑干发作的发生具有随机性，与引燃依赖性前脑发作进展的顺序无关。经历过癫痫发作和AGS-naive的gepr -9在脑干癫痫发作的发生率上没有差异，这表明遗传易感性是前脑癫痫引起的脑干癫痫发作回路激活的主要因素。这种脑干发作活动似乎模拟了在人类部分性发作中观察到的继发性泛化的相关方面。
Forebrain seizures were kindled in rats by daily electrical stimulation of the amygdala. Genetically epilepsy-prone rats scoring 9 (GEPR-9s) on the seizure severity scale during audiogenic seizure (AGS) screening (''brainstem seizure-experienced'') required fewer stimulations to achieve fully kindled seizures (forelimb clonus with rearing and falling) than control rats. AGS-naive GEPR-9s required an intermediate number of stimulations, indicating a role for both genetic predisposition and previous acoustically evoked brainstem seizure experience. Other forebrain kindling indices such as afterdischarge threshold/duration and seizure latency/duration also involved genetic as well as phenotypic (previous seizure experience) factors. In most GEPR-9s in both groups, severe brainstem seizures occurred after forebrain stimulation. The occurrence of brainstem seizures had a random nature and was not related to the sequence of kindling-dependent forebrain seizure progression. The lack of a difference in the occurrence of brainstem seizures between seizure-experienced and AGS-naive GEPR-9s suggest that genetic predisposition is the major factor in forebrain seizure-induced activation of brainstem seizure circuitry. This brainstem seizure activity appears to model pertinent aspects of secondary generalization observed in human partial seizures.