Dietary Carotenoids, Vitamins A, C, and E, and Macular Degeneration-Reply
Dietary Carotenoids, Vitamins A, C, and E, and Macular Degeneration-Reply
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膳食类胡萝卜素、维生素 A、C 和 E，与黄斑变性-Reply
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
R. Sperduto
中科院分区：
文献类型：
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作者：
J. Seddon;W. Willett;R. Sperduto
在回答。-胡萝卜素或任何一种维生素的随机试验将无法回答所有抗氧化剂在与年龄有关的眼病的发生或进展中的作用的所有问题。随附文章的社论1提醒我们，临床试验的成功在于“给适当的人群以适当的剂量、适当的时间给予适当的营养”。如果不满足这些要求中的任何一个，即使存在效果，也会降低或消除发现效果的可能性。”正如我们在文章中所讨论的，观察性研究和临床试验都有助于我们理解抗氧化剂以及其他营养物质与慢性眼病风险之间的关系。
In Reply. —Randomized trials of beta carotene or any one vitamin will not be able to answer all questions about the role of all antioxidants in the development or progression of age-related eye disease. The Editorial 1 accompanying our article reminds us that the success of the clinical trials in finding an association "depends on giving the appropriate nutrient, in the appropriate dose, for an appropriate period of time, to an appropriate population. Failing to meet any one of these requirements will reduce or eliminate the probability of finding an effect even if one exists." As we discussed in our article, observational studies and clinical trials both can contribute to our understanding of the relationship between antioxidants as well as other nutrients and risk of chronic eye disease.