Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations
Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations
复制标题
前额皮质促肾上腺皮质激素释放因子神经元控制挑战性情况下的行为风格选择
DOI：
10.1016/j.neuron.2020.01.033
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发表时间：
2020-04-22
期刊：
影响因子：
16.2
通讯作者：
Zhou, Jiang-Ning
中科院分区：
文献类型：
--
作者：
Chen, Peng;Lou, Shihao;Zhou, Jiang-Ning
对于应激源，个体采取不同的行为方式，这些行为方式对生存是必不可少的，并形成了对应激相关障碍的不同易感性的基础。促肾上腺皮质激素释放因子(CRF)和内侧前额叶皮质(MPFC)在应激行为反应中的作用已被广泛研究，但对mPFC CRF神经元的作用知之甚少。利用形态学、电生理学和钙成像方法，我们将mPFC CRF神经元描述为直接参与尾部悬吊挑战的GABA能抑制中间神经元的一个独特亚型。基因消融或化学抑制背侧mPFC(DmPFC)CRF神经元在尾部悬吊和强迫游泳刺激下的不动增加，并诱导社交回避行为，而激活在相同的措施下有相反的作用。此外，CRF神经元活性的增加提高了对反复的社会失败压力的持久弹性。这些结果揭示了mPFC CRF中间神经元在应激状态下双向控制动机行为风格选择中的关键作用。
In response to stressors, individuals adopt different behavioral styles, which are essential for survival and form the basis of differential susceptibility to stress-related disorders. Corticotropin-releasing factor (CRF) and the medial prefrontal cortex (mPFC) have predominantly been studied in behavioral response to stress, while the role of mPFC CRF neurons is poorly understood. Using morphology, electrophysiology, and calcium imaging approaches, we characterized mPFC CRF neurons as a unique subtype of GABAergic inhibitory interneurons that were directly engaged in the tail suspension challenge. Genetic ablation or chemogenetic inhibition of dorsal mPFC (dmPFC) CRF neurons increased immobility under the tail-suspension and forced-swimming challenges and induced social avoidance behavior, whereas activation had the opposite effect on the same measures. Furthermore, increasing CRF neuronal activity promoted durable resilience to repeated social defeat stress. These results uncover a critical role of mPFC CRF interneurons in bidirectionally controlling motivated behavioral style selection under stress.