First linezolid-resistant clinical isolates of Mycobacterium tuberculosis
First linezolid-resistant clinical isolates of Mycobacterium tuberculosis
复制标题
DOI：
10.1128/aac.01113-06
复制
发表时间：
2007-04-01
影响因子：
4.9
通讯作者：
Hillemann, Doris
中科院分区：
文献类型：
--
作者：
Richter, Elvira;Ruesch-Gerdes, Sabine;Hillemann, Doris
在210株多重耐药结核分枝杆菌菌株中发现4株（1.9%）对利奈唑胺耐药。利奈唑胺的MIC为4 μ g/ml（1株）和8 μ g/ml（3株）。由于在潜在的靶基因中未检测到突变，因此耐药机制仍不清楚。
Linezolid resistance was found in 4 (1.9%) of 210 multidrug-resistant Mycobacterium tuberculosis strains. The MICs of linezolid were 4 mu g/ml (one strain) and 8 mu g/ml (three strains). Since no mutations were detected in potential target genes, the mechanism of resistance remains unclear.