DETERMINATION OF LEFT-VENTRICULAR CHAMBER STIFFNESS FROM THE TIME FOR DECELERATION OF EARLY LEFT-VENTRICULAR FILLING
DETERMINATION OF LEFT-VENTRICULAR CHAMBER STIFFNESS FROM THE TIME FOR DECELERATION OF EARLY LEFT-VENTRICULAR FILLING
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DOI：
10.1161/01.cir.92.7.1933
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发表时间：
1995-10-01
期刊：
影响因子：
37.8
通讯作者：
CHENG, CP
中科院分区：
文献类型：
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作者：
LITTLE, WC;OHNO, M;CHENG, CP
背景一种无创测量左心室（LV）腔刚度（K-LV）的方法在临床上是有用的。我们的理论分析预测，K-LV可由LV早期充注减速时间（t(dec)）由K-LV=rho计算。信用证。(π/ 2。1/t(dec))(2)式中，rho=血密度，L=有效二尖瓣长度，A=二尖瓣面积。方法和结果我们在8只有意识的狗身上验证了这一假设，这些狗用微压计测量左室压力(P)，用声微米计测量体积(V)。K-LV测定为LV - P-V袢舒张后期部分的斜率。使用三种分级剂量的苯肾上腺素，K-LV变化范围为0.99+/-0.35至2.58+/-0.92 mmhg /mL。我们假设rho=1.0, L/A=3.4。因此，我们预测K-LV=(0.08/t(dec))(2)。根据左室容积（dV/dt）的导数确定左室填充模式。从早期灌浆高峰到早期灌浆结束测量T （dec）。预测K-LV与实际K-LV密切相关(r= 0.94， SEE=0.06 mm Hg/mL， P
Background A noninvasive measure of left ventricular (LV) chamber stiffness (K-LV) would be clinically useful. Our theoretical analysis predicts that K-LV can be calculated from the time for deceleration of LV early filling (t(dec)) byK-LV=rho . L/A .(pi/2 . 1/t(dec))(2)where rho=density of blood, L=effective mitral length, and A=mitral area.Methods and Results We tested this hypothesis in eight conscious dogs instrumented for measurement of LV pressure (P) with use of a micromanometer and volume (V) with use of sonomicrometers. K-LV was determined as the slope of the late diastolic portion of the LV P-V loop. K-LV was varied from 0.99+/-0.35 to 2.58+/-0.92 mm Hg/mL with use of three graded doses of phenylephrine. We assumed that rho=1.0 and that L/A=3.4. Thus, we predicted that K-LV=(0.08/t(dec))(2). The LV filling pattern was determined from the derivative of LV volume (dV/dt). t(dec) was measured from peak early filling to the end of early filling. Predicted K-LV and actual K-LV were closely correlated (r=.94, SEE=0.06 mm Hg/mL, P