Neuromelanin-sensitive magnetic resonance imaging in disease differentiation for parkinsonism or neurodegenerative disease affecting the basal ganglia
Neuromelanin-sensitive magnetic resonance imaging in disease differentiation for parkinsonism or neurodegenerative disease affecting the basal ganglia
复制标题
神经黑素敏感性磁共振成像在帕金森综合征或基底节神经退行性疾病鉴别诊断中的应用
DOI：
10.1016/j.parkreldis.2021.05.002
复制
发表时间：
2021-05-15
影响因子：
4.1
通讯作者：
Tomimoto, Hidekazu
中科院分区：
文献类型：
--
作者：
Matsuura, Keita;Ii, Yuichiro;Tomimoto, Hidekazu
简介：一些报告表明，使用 3T 磁共振成像的神经黑色素敏感磁共振成像 (NMI) 可用于帕金森病 (PD)、进行性核上性麻痹 (PSP) 和其他神经系统疾病的鉴别诊断。然而，以往的研究中案例数量还不够。我们的目的是确定 NMI 与 PD 及相关疾病严重程度之间的关系，从而确立 NMI 在诊断神经系统疾病方面的诊断效用。方法：我们纳入了 591 名接受 NMI 的帕金森病患者（去除重复后为 531 名受试者）。分析每例患者的蓝斑对比度（LCCR）和黑质致密部（SNc）面积。结果：患者临床诊断如下：疾病对照组（DCG）11例，PD患者244例，PSP患者49例，多系统萎缩伴帕金森病为主的患者19例。此外，一些患者被诊断患有路易体痴呆、血管性帕金森症和药物性帕金森症。 PD和PSP患者的SNc明显小于DCG患者。 PD患者LC-CR低于DCG；此外，PD患者的LC-CR显着低于PSP患者。我们发现，LC-CR 的接受者操作特征曲线下面积为 0.85，表明诊断功效，是区分 PD 和 PSP 的有前途的生物标志物。结论：NMI 有效有助于区分神经退行性疾病，例如 PD 和 PSP。
Introduction: Several reports have shown that neuromelanin-sensitive magnetic resonance imaging (NMI) using 3T magnetic resonance imaging is useful for the differential diagnosis of Parkinson's disease (PD), progressive supranuclear palsy (PSP), and other neurological diseases. However, the number of cases in previous studies has been insufficient. We aimed to determine the relationship between NMI and severity of PD and related disorders, and thereby establish the diagnostic utility of NMI for diagnosing neurological diseases.Methods: We enrolled 591 patients (531 subjects after removal of duplicates) with parkinsonism who underwent NMI. The contrast ratio of the locus coeruleus (LCCR) and the area of the substantia nigra pars compacta (SNc) were analyzed in each patient.Results: The patients' clinical diagnoses were as follows: 11 patients in the disease control group (DCG), 244 patients with PD, 49 patients with PSP, and 19 patients with multiple system atrophy with predominant parkinsonism. Additionally, some patients were diagnosed with dementia with Lewy bodies, vascular parkinsonism, and drug-induced parkinsonism. SNc in the patients with PD and PSP was significantly smaller than that in DCG. LC-CR in the patients with PD was lower than that in DCG; furthermore, LC-CR in the patients with PD was significantly lower than that in the patients with PSP. We found that an area under the receiver-operating characteristic curve, indicating diagnostic efficacy, of 0.85 for LC-CR is a promising biomarker for differentiating PD from PSP.Conclusion: NMI effectively contributes to differentiating neurodegenerative diseases, such as PD and PSP.