Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology.
Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology.
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DOI：
10.3389/fonc.2017.00145
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发表时间：
2017
影响因子：
4.7
通讯作者：
Postovit LM
中科院分区：
文献类型：
--
作者：
Bilyk O;Coatham M;Jewer M;Postovit LM
上皮细胞向间质细胞转化（EMT）是一个重要的生理过程，在整个人类的寿命。除了促进生长中的胚胎内各种组织的发育外，EMT还负责成年后的伤口愈合和组织再生。在这篇综述中，我们强调了EMT在女性生殖器官（卵巢和子宫）的发育和正常功能中的重要性，并描述了EMT的失调如何导致病理条件，如子宫内膜异位症，子宫腺肌病和癌变。我们还总结了目前有关EMT在卵巢癌和子宫内膜癌背景下的文献，特别关注分子机制和肿瘤微环境如何控制癌细胞的可塑性，耐药性和转移。
Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In this review, we highlight the importance of EMT in the development and normal functioning of the female reproductive organs (the ovaries and the uterus) and describe how dysregulation of EMT can lead to pathological conditions, such as endometriosis, adenomyosis, and carcinogenesis. We also summarize the current literature relating to EMT in the context of ovarian and endometrial carcinomas, with a particular focus on how molecular mechanisms and the tumor microenvironment can govern cancer cell plasticity, therapy resistance, and metastasis.