Advances in therapy for melanoma brain metastases
Advances in therapy for melanoma brain metastases
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DOI：
10.1016/j.clindermatol.2012.08.008
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发表时间：
2013-05-01
影响因子：
2.7
通讯作者：
Kluger, Harriet M.
中科院分区：
文献类型：
--
作者：
Flanigan, Jaclyn C.;Jilaveanu, Lucia B.;Kluger, Harriet M.
黑色素瘤细胞经常转移到大脑，大约50%的转移性黑色素瘤患者发生颅内疾病。从历史上看，中枢神经系统播散预示着预后非常差。黑色素瘤全身治疗的最新进展，得到改善的脑病变局部治疗控制的支持，使这些患者的中位生存期更好。我们回顾了目前治疗黑色素瘤脑转移患者的局部和全身方法。(C)2013 Elsevier Inc. All rights reserved.
Melanoma cells frequently metastasize to the brain, and approximately 50% of patients with metastatic melanoma develop intracranial disease. Historically, central nervous system dissemination has portended a very poor prognosis. Recent advances in systemic therapies for melanoma, supported by improved local therapy control of brain lesions, have resulted in better median survival for these patients. We review current local and systemic approaches for patients with melanoma brain metastases. (C) 2013 Elsevier Inc. All rights reserved.