Expression of chemokine receptors by lung T cells from normal and asthmatic subjects
Expression of chemokine receptors by lung T cells from normal and asthmatic subjects
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DOI：
10.4049/jimmunol.166.4.2842
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发表时间：
2001-02-15
影响因子：
4.4
通讯作者：
Wardlaw, AJ
中科院分区：
文献类型：
--
作者：
Campbell, JJ;Brightling, CE;Wardlaw, AJ
肺是一个重要的三级淋巴器官，在健康和疾病中，T细胞通过肺不断运输。T细胞迁移受血管内皮和组织中表达的粘附受体和趋化因子的组合控制，通常以器官特异性方式。这导致不同T细胞亚群的选择性积累，这一过程称为淋巴细胞归巢。有证据表明，一个独特的肺归巢途径，但没有具体的肺归巢受体已被描述。我们分析了肺T细胞的趋化因子受体谱，以确定肺T细胞与其他器官（如肠道和皮肤）共享归巢途径的程度。此外，我们比较了正常和哮喘个体中受体的表达，以确定健康和疾病中是否使用了不同的途径。我们观察到肺T细胞表达的趋化因子和粘附受体的谱与肠道和皮肤归巢T细胞的不同，尽管没有发现肺特异性趋化因子受体。特别是，肺T细胞表达CCR5和CXCR3，但没有CeR9或皮肤淋巴细胞Ag，只有低水平的CCR4和α 4 β 7。在正常与哮喘受试者的肺T细胞之间没有观察到差异。这项研究为肺归巢途径与其他粘膜器官（如肠道）分离的概念提供了额外的支持，并表明在正常稳态和Th2型炎症反应中控制T细胞迁移的趋化因子途径是相似的。
The lung is an important tertiary lymphoid organ with constant trafficking of T cells through the lung in both health and disease. T cell migration is controlled by a combination of adhesion receptors and chemokines expressed on vascular endothelium and in the tissue, often in an organ-specific manner. This leads to selective accumulation of different T cell subsets, a process called lymphocyte homing. There is evidence for a distinct lung-homing pathway, but no specific lung-homing receptors have been described. We analyzed the chemokine receptor profile of lung T cells to determine the extent to which lung T cells shared homing pathways with other organs such as the gut and skin. In addition, we compared expression of receptors in normal and asthmatic individuals to determine whether different pathways were used in health and disease, We observed that lung T cells expressed a profile of chemokine and adhesion receptors distinct from that of gut- and skin-homing T cells although no chemokine receptor specific for the lung was found. In particular, lung T cells expressed CCR5 and CXCR3, but not CeR9 or cutaneous lymphocyte Ag, and only low levels of CCR4 and alpha (4)beta (7). No differences were observed between lung T cells from normal vs asthmatic subjects. This study provides added support far the concept of a lung-homing pathway separate from other mucosal organs such as the gut and suggests that the chemokine pathways that control T cell migration in normal homeostasis and Th2-type inflammatory responses are similar.