Development of the human fetal insular cortex: study of the gyration from 13 to 28 gestational weeks
Development of the human fetal insular cortex: study of the gyration from 13 to 28 gestational weeks
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DOI：
10.1007/s00429-007-0161-1
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发表时间：
2007-12-01
影响因子：
3.1
通讯作者：
Mertens, P.
中科院分区：
文献类型：
--
作者：
Afif, A.;Bouvier, R.;Mertens, P.
为了描述岛沟和脑回发育的形态学阶段，我们对21个胎脑进行了宏观研究，在13至28孕周（GWs）期间没有发现异常。特别关注岛和岛周结构发育过程中的形态学外观，特别是岛、大脑中央区域和脑盖的旋转和弯曲，以及这些区域的血管化。岛周沟和中央沟（岛沟和脑沟）是人类胎儿大脑半球外侧表面最早发现的宏观结构，右半球发育较早。在这里，我们描述了与胎龄密切相关的岛回和岛沟发育的五个阶段：第1阶段：13-17胎龄时第一个沟的出现，第2阶段：18-19胎龄时岛周沟的发育，第3阶段：20-22胎龄时岛中央沟和岛盖化，第4阶段：24-26胎龄时岛后部覆盖，第5阶段：27-28胎龄时岛侧裂隙闭合。我们提供的证据表明，皮层的成熟（形成和旋转）和大脑外侧表面的血管化始于岛叶区，这表明该区域是皮层发育的中心区域。
To describe the morphological stages of insular sulci and gyri development we carried out a macroscopical study on 21 human fetal brains, showing no anomalies, from 13 to 28 gestational weeks (GWs). Particular focus was given to morphological appearance during the development of insular and periinsular structures, especially the gyration and sulcation of the insula, central cerebral region and opercula, as well as the vascularization of these regions. The periinsular sulci and the central (insular and cerebral) sulci were the first macroscopical structures identified on the lateral surface of the human fetal cerebral hemisphere with earlier development on the right hemisphere. Here we describe five stages of insular gyral and sulcal development closely related to gestational age: stage 1: appearance of the first sulcus at 13-17 GWs, stage 2: development of the periinsular sulci at 18-19 GWs, stage 3: central sulci and opercularization of the insula at 20-22 GWs, stage 4: covering of the posterior insula at 24-26 GWs, stage 5: closure of the sylvian fissure at 27-28 GWs. We provide evidence that cortical maturation (sulcation and gyration) and vascularization of the lateral surface of the brain starts with the insular region, suggesting that this region is a central area of cortical development.